REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .28. CYCLOOCTA[B]PYRAN DERIVATIVES WITH LOCAL-ANESTHETIC, PLATELET ANTIAGGREGATING AND OTHER ACTIVITIES

被引：0

作者：

LONGOBARDI, M ^{[1
]}

BARGAGNA, A ^{[1
]}

MARIANI, E ^{[1
]}

SCHENONE, P ^{[1
]}

DAMICO, M ^{[1
]}

FALCIANI, M ^{[1
]}

FILIPPELLI, W ^{[1
]}

CONTALDI, C ^{[1
]}

机构：

[1] UNIV NAPLES 2,FAC MED & CHIRURG,IST FARMACOL & TOSSICOL,I-80138 NAPLES,ITALY

来源：

FARMACO | 1995年 / 50卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The synthesis of some N,N-disubstituted 4-amino-5,6,7,8,9,10-hexahydro-3-phenyl-2H-cycloocta[b]pyran-2-ones by reaction of phenylchloroketene with a series of N,N-disubstituted 2-aminomethylenecyclooctanones , followed by dehydrochlorination in situ of the primary adducts with DBN, is described. The dimethylamino derivative showed a local anesthetic activity in mice superior to that of lidocaine, and some compounds exhibited a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as weak antiarrhythmic and antiinflammatory activities in rats.

引用

页码：55 / 59

页数：5

共 45 条

[31] REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENE KETONES - SYNTHESIS OF 2H,5H-PYRAN[3,2-C][1]BENZOPYRAN DERIVATIVES
MOSTI, L
SCHENONE, P
MENOZZI, G
CHIMICA & L INDUSTRIA, 1979, 61 (10): : 768 - 768
[32] REACTION OF N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES WITH TOSYL ISOCYANATE - SYNTHESIS OF AMINO-DISUBSTITUTED "2-ACYL-3-AMINO-N-TOSYLPROPENAMIDES, N,N-(3-AMINO-1-ALKYL-2-PROPENYLIDENE) AND N,N-[2-(AMINOMETHYLENE)CYCLOHEXYLIDENE]TOSYLAMIDES
ROMUSSI, G
PARODI, B
BIGNARDI, G
MENOZZI, G
SCHENONE, P
FARMACO-EDIZIONE SCIENTIFICA, 1986, 41 (07): : 539 - 547
[33] REACTION OF SULFENE WITH HETEROCYCLIC N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .5. SYNTHESIS OF 1,2-OXATHIINO[5,6-C]PYRIDINE AND 1,2-OXATHIINO[5,6-C]QUINOLINE DERIVATIVES
MOSTI, L
SCHENONE, P
MENOZZI, G
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1979, 16 (01) : 177 - 182
[34] REACTION OF SULFENE AND DICHLOROKETENE WITH OPEN-CHAIN N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES - SYNTHESIS OF N,N-DISUBSTITUTED 4-AMINO-3,4-DIHYDRO-(5-METHYL-6-PHENYL)(5,6-DIPHENYL)-1,2-OXATHIIN 2,2-DIOXIDES AND OF 4-AMINO-3-CHLORO-5-METHYL-6-PHENYL-2H-PYRAN-2-ONES
BARGAGNA, A
SCHENONE, P
BONDAVALLI, F
LONGOBARDI, M
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1980, 17 (06) : 1201 - 1206
[35] REACTION OF SULFENE WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .6. SYNTHESIS OF N,N-DISUBSTITUTED 4-AMINO-3,4-DIHYDRO-6-PHENYL-1,2-OXATHIIN 2,2-DIOXIDES AND OF 4-METHYLPHENYLAMINO-3,4-DIHYDRO-5,6-POLYMETHYLEN-1,2-OXATHIIN 2,2-DIOXIDES
EVANGELISTI, F
SCHENONE, P
BARGAGNA, A
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1979, 16 (02) : 217 - 220
[36] REACTION OF SULFENE AND DICHLOROKETENE WITH OPEN-CHAIN N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES - SYNTHESIS OF 4-DIALKYLAMINO-3,4-DIHYDRO-6-METHYL-5-PHENYL-1,2-OXATHIIN 2,2-DIOXIDES AND OF N,N-DISUBSTITUTED 4-AMINO-3-CHLORO-(6-METHYL-5-PHENYL)(6-BENZYL)-2H-PYRAN-2-ONES
BARGAGNA, A
EVANGELISTI, F
SCHENONE, P
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1981, 18 (01) : 111 - 116
[37] 3,5-DIPHENYL-1H-PYRAZOLE DERIVATIVES .4. N,N-DISUBSTITUTED 3-(3,5-DIPHENYL-1H-PYRAZOL-1-YL)PROPANAMIDES AND 3-(3,5-DIPHENYL-1H-PYRAZOL-1-YL)PROPANAMINES WITH SEDATIVE, PLATELET ANTIAGGREGATING AND LOCAL-ANESTHETIC ACTIVITIES
BONDAVALLI, F
BRUNO, O
RANISE, A
SCHENONE, P
LOSASSO, C
DONNOLI, D
STELLA, L
MARMO, E
FARMACO, 1990, 45 (02): : 137 - 146
[38] REACTION OF SULFENE AND DICHLOROKETENE WITH OPEN-CHAIN N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES - SYNTHESIS OF 4-DIALKYLAMINO-3,4-DIHYDRO-5,6-DIMETHYL-1,2-OXATHIIN 2,2-DIOXIDES AND OF 6,(5)(DI)ALKYL-3-CHLORO-4-METHYLPHENYLAMINO-2H-PYRAN-2-ONES
BARGAGNA, A
SCHENONE, P
BONDAVALLI, F
LONGOBARDI, M
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1980, 17 (01) : 33 - 37
[39] REACTION OF DICHLOROKETENE AND SULFENE WITH N,N-DISUBSTITUTED 2-AMINOMETHYLENE-1-INDANONES - SYNTHESIS OF INDENO[1,2-B]PYRAN AND INDENO[2,1-E]-1,2-OXATHIIN DERIVATIVES
MOSTI, L
BIGNARDI, G
EVANGELISTI, F
SCHENONE, P
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1976, 13 (06) : 1201 - 1203
[40] 3,5-DIPHENYL-1H-PYRAZOLE DERIVATIVES .12. N-SUBSTITUTED 4-AMINO-1-(2-HYDROXY OR 2-ALKYLAIMINOETHYL)-3,5-DIPHENYL-1H-PYRAZOLES WITH LOCAL-ANESTHETIC, ANALGESIC AND PLATELET ANTIAGGREGATING ACTIVITIES
BRUNO, O
RANISE, A
BONDAVALLI, F
SCHENONE, S
DAMICO, M
FALCIANI, M
VACCA, C
FILIPPELLI, A
FARMACO, 1994, 49 (09): : 533 - 540

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