REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .28. CYCLOOCTA[B]PYRAN DERIVATIVES WITH LOCAL-ANESTHETIC, PLATELET ANTIAGGREGATING AND OTHER ACTIVITIES

The synthesis of some N,N-disubstituted 4-amino-5,6,7,8,9,10-hexahydro-3-phenyl-2H-cycloocta[b]pyran-2-ones by reaction of phenylchloroketene with a series of N,N-disubstituted 2-aminomethylenecyclooctanones , followed by dehydrochlorination in situ of the primary adducts with DBN, is described. The dimethylamino derivative showed a local anesthetic activity in mice superior to that of lidocaine, and some compounds exhibited a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as weak antiarrhythmic and antiinflammatory activities in rats.