REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .28. CYCLOOCTA[B]PYRAN DERIVATIVES WITH LOCAL-ANESTHETIC, PLATELET ANTIAGGREGATING AND OTHER ACTIVITIES

被引：0

作者：

LONGOBARDI, M ^{[1
]}

BARGAGNA, A ^{[1
]}

MARIANI, E ^{[1
]}

SCHENONE, P ^{[1
]}

DAMICO, M ^{[1
]}

FALCIANI, M ^{[1
]}

FILIPPELLI, W ^{[1
]}

CONTALDI, C ^{[1
]}

机构：

[1] UNIV NAPLES 2,FAC MED & CHIRURG,IST FARMACOL & TOSSICOL,I-80138 NAPLES,ITALY

来源：

FARMACO | 1995年 / 50卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The synthesis of some N,N-disubstituted 4-amino-5,6,7,8,9,10-hexahydro-3-phenyl-2H-cycloocta[b]pyran-2-ones by reaction of phenylchloroketene with a series of N,N-disubstituted 2-aminomethylenecyclooctanones , followed by dehydrochlorination in situ of the primary adducts with DBN, is described. The dimethylamino derivative showed a local anesthetic activity in mice superior to that of lidocaine, and some compounds exhibited a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as weak antiarrhythmic and antiinflammatory activities in rats.

引用

页码：55 / 59

页数：5

共 45 条

[1] REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .26. CYCLOHEPTA[B]PYRAN DERIVATIVES WITH PLATELET ANTIAGGREGATING AND OTHER ACTIVITIES
BARGAGNA, A
LONGOBARDI, M
MARIANI, E
SCHENONE, P
ROSSI, F
FALZARANO, C
DAMICO, M
FALZARANO, C
FARMACO, 1992, 47 (03): : 345 - 355
[2] REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES - 2H-1-BENZOPYRAN DERIVATIVES WITH PLATELET ANTIAGGREGATING AND OTHER ACTIVITIES
LONGOBARDI, M
BARGAGNA, A
MARIANI, E
SCHENONE, P
DAMICO, M
FILIPPELLI, A
FALZARANO, C
LAMPA, E
FARMACO, 1993, 48 (08): : 1121 - 1130
[3] REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .25. BENZO[6,7]CYCLOHEPTA[1,2-B]PYRAN DERIVATIVES WITH PLATELET ANTIAGGREGATING AND OTHER ACTIVITIES
BARGAGNA, A
LONGOBARDI, M
MARIANI, E
SCHENONE, P
CENICOLA, ML
LOSASSO, C
CARNEVALE, M
MARMO, E
FARMACO, 1991, 46 (03): : 461 - 475
[4] REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .21. 2H-[1] BENZOTHIEPINO [5,4-B] PYRAN DERIVATIVES WITH LOCAL-ANESTHETIC AND ANTIARRHYTHMIC ACTIVITIES
LONGOBARDI, M
BARGAGNA, A
MARIANI, E
SCHENONE, P
VITAGLIANO, S
STELLA, L
DISARNO, A
MARMO, E
FARMACO, 1990, 45 (04): : 399 - 404
[5] REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .22. 2H,5H-[1] BENZOTHIOPYRANO [4,3-B] PYRAN DERIVATIVES WITH PLATELET ANTIAGGREGATING ACTIVITY
BARGAGNA, A
LONGOBARDI, M
MARIANI, E
SCHENONE, P
LOSASSO, C
ESPOSITO, G
FALZARANO, C
MARMO, E
FARMACO, 1990, 45 (04): : 405 - 413
[6] REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .24. 2H-PYRANO[3,2-D]-1-BENZOXEPIN DERIVATIVES WITH PLATELET ANTIAGGREGATING AND OTHER ACTIVITIES
LONGOBARDI, M
BARGAGNA, A
MARIANI, E
SCHENONE, P
LOSASSO, C
CENICOLA, ML
DANTONIO, M
MARMO, E
FARMACO, 1991, 46 (03): : 449 - 460
[7] REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .17. SYNTHESIS OF 2H-[1]BENZOTHIEPINO[5,4-B]PYRAN DERIVATIVES
MENOZZI, G
MOSTI, L
SCHENONE, P
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1986, 23 (02) : 449 - 454
[8] REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .8. SYNTHESIS OF N,N-DISUBSTITUTED 4-AMINO-3-CHLORO-6-PHENYL-2H-PYRAN-2-ONES
BARGAGNA, A
EVANGELISTI, F
SCHENONE, P
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1979, 16 (01) : 93 - 96
[9] REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .18. SYNTHESIS OF N,N-DISUBSTITUTED 4-AMINO-3-PHENYL-2H-NAPHTHO[1,2-B]PYRAN-2-ONES
BARGAGNA, A
SCHENONE, P
LONGOBARDI, M
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1986, 23 (04) : 1067 - 1070
[10] REACTION OF KETENES WITH N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES .16. SYNTHESIS OF N,N-DISUBSTITUTED 4-AMINO-5,6-TETRAMETHYLENE-3-PHENYL-2-PYRANONES
BARGAGNA, A
SCHENONE, P
LONGOBARDI, M
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1985, 22 (06) : 1471 - 1473

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