CHARACTERISTIC ANTITUMOR-ACTIVITY OF CYTARABINE OCFOSFATE AGAINST HUMAN COLORECTAL ADENOCARCINOMA XENOGRAFTS IN NUDE-MICE

被引：0

作者：

KOGA, K ^{[1
]}

IIZUKA, E ^{[1
]}

SATO, A ^{[1
]}

EKIMOTO, H ^{[1
]}

OKADA, M ^{[1
]}

机构：

[1] NIPPON KAYAKU CO LTD,PHARMACEUT GRP,DEPT ANTICANC DRUGS,KITA KU,TOKYO 115,JAPAN

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1995年 / 36卷 / 06期

关键词：

CYTARABINE OCFOSFATE; COLORECTAL ADENOCARCINOMA; NUDE MICE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The antitumor activity of cytarabine ocfosfate (SPAC) was tested against human colorectal, gastric and lung adenocarcinoma xenografts in nude mice in comparison with the activities of various antitumor drugs used clinically. SPAC showed higher therapeutic efficacy against human colorectal adenocarcinoma xenografts than against human gastric and lung adenocarcinoma xenografts. SPAC was effective against three of four human colorectal adenocarcinoma xenografts, with efficacy higher than that of 1-beta-D-arabinofuranosylcytosine, fluorouracil, cisplatin, doxorubicin, pirarubicin and vindesine sulfate, but lower than that of mitomycin C and cyclophosphamide. These results indicate that SPAC may be useful for induction and/or postoperative chemotherapy against colorectal adenocarcinomas.

引用

页码：459 / 462

页数：4