MELATONIN PHASE ADVANCES CIRCADIAN-RHYTHM

被引：18

作者：

ATTENBURROW, MEJ ^{[1
]}

DOWLING, BA ^{[1
]}

SARGENT, PA ^{[1
]}

SHARPLEY, AL ^{[1
]}

COWEN, PJ ^{[1
]}

机构：

[1] UNIV OXFORD,LITTLEMORE HOSP,DEPT PSYCHIAT,OXFORD OX4 4XN,ENGLAND

来源：

PSYCHOPHARMACOLOGY | 1995年 / 121卷 / 04期

关键词：

MELATONIN; CIRCADIAN RHYTHM;

D O I：

10.1007/BF02246501

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effect of acute (1 day) and subacute (7 days) treatment with melatonin (0.5 mg) on the endogenous rhythms of melatonin secretion in 12 healthy male volunteers, using a placebo-controlled, double-blind, cross-over design. Melatonin given at 1700 h for 7 days significantly advanced the onset of endogenous melatonin secretion, while a single dose was without effect. These data are consistent with the hypothesis that melatonin plays a role in the organisation of circadian rhythms in humans and suggests that appropriately timed melatonin administration may provide a means of altering the timing of circadian cycles.

引用

页码：503 / 505

页数：3

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