DESIGN OF A COVALENT PEPTIDE HETERODIMER FOR SEQUENCE-SPECIFIC RECOGNITION IN THE MINOR-GROOVE OF DOUBLE-HELICAL DNA

被引：72

作者：

MRKSICH, M ^{[1
]}

DERVAN, PB ^{[1
]}

机构：

[1] CALTECH,ARNOLD & MABEL BECKMAN LABS CHEM SYNTH,PASADENA,CA 91125

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1994年 / 116卷 / 08期

关键词：

D O I：

10.1021/ja00087a088

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：3663 / 3664

页数：2

共 16 条

[1] DESIGN OF SEQUENCE-SPECIFIC DNA-BINDING MOLECULES [J].

DERVAN, PB .

SCIENCE, 1986, 232 (4749) :464-471

[2] STRUCTURAL-ANALYSIS OF COVALENT PEPTIDE DIMERS, BIS(PYRIDINE-2-CARBOXAMIDONETROPSIN)(CH2)3-6, IN COMPLEX WITH 5'-TGACT-3' SITES BY 2-DIMENSIONAL NMR [J].

DWYER, TJ ;

GEIERSTANGER, BH ;

MRKSICH, M ;

DERVAN, PB ;

WEMMER, DE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (22) :9900-9906

[3] DESIGN AND BINDING OF A DISTAMYCIN-A ANALOG TO D(CGCAAGTTGGC)BULLET-D(GCCAACTTGCG) - SYNTHESIS, NMR-STUDIES, AND IMPLICATIONS FOR THE DESIGN OF SEQUENCE-SPECIFIC MINOR GROOVE BINDING OLIGOPEPTIDES [J].

DWYER, TJ ;

GEIERSTANGER, BH ;

BATHINI, Y ;

LOWN, JW ;

WEMMER, DE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (15) :5911-5919

[4] NMR CHARACTERIZATION OF A HETEROCOMPLEX FORMED BY DISTAMYCIN AND ITS ANALOG 2-IMD WITH D(CGCAAGTTGGC)-D(GCCAACTTGCG) - PREFERENCE FOR THE 1/1/1 2-IMD-DST-DNA COMPLEX OVER THE 2/1 2-IMD-DNA AND THE 2/1 DST-DNA COMPLEXES [J].

GEIERSTANGER, BH ;

DWYER, TJ ;

BATHINI, Y ;

LOWN, JW ;

WEMMER, DE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (11) :4474-4482

[5] STRUCTURAL AND DYNAMIC CHARACTERIZATION OF THE HETERODIMERIC AND HOMODIMERIC COMPLEXES OF DISTAMYCIN AND 1-METHYLIMIDAZOLE-2-CARBOXAMIDE-NETROPSIN BOUND TO THE MINOR-GROOVE OF DNA [J].

GEIERSTANGER, BH ;

JACOBSEN, JP ;

MRKSICH, M ;

DERVAN, PB ;

WEMMER, DE .

BIOCHEMISTRY, 1994, 33 (10) :3055-3062

[6] ISOHELICAL ANALYSIS OF DNA GROOVE-BINDING DRUGS [J].

GOODSELL, D ;

DICKERSON, RE .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (05) :727-733

[7] MOLECULAR RECOGNITION BETWEEN OLIGOPEPTIDES AND NUCLEIC-ACIDS - MONOCATIONIC IMIDAZOLE LEXITROPSINS THAT DISPLAY ENHANCED GC SEQUENCE DEPENDENT DNA-BINDING [J].

KISSINGER, K ;

KROWICKI, K ;

DABROWIAK, JC ;

LOWN, JW .

BIOCHEMISTRY, 1987, 26 (18) :5590-5595

[8] THE MOLECULAR-ORIGIN OF DNA DRUG SPECIFICITY IN NETROPSIN AND DISTAMYCIN [J].

KOPKA, ML ;

YOON, C ;

GOODSELL, D ;

PJURA, P ;

DICKERSON, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (05) :1376-1380

[9] ENHANCED SEQUENCE-SPECIFIC RECOGNITION IN THE MINOR-GROOVE OF DNA BY COVALENT PEPTIDE DIMERS - BIS(PYRIDINE-2-CARBOXAMIDONETROPSIN)(CH2)3-6 [J].

MRKSICH, M ;

DERVAN, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (22) :9892-9899

[10] ANTIPARALLEL SIDE-BY-SIDE HETERODIMER FOR SEQUENCE-SPECIFIC RECOGNITION IN THE MINOR GROOVE OF DNA BY A DISTAMYCIN 1-METHYLIMIDAZOLE-2-CARBOXAMIDE-NETROPSIN PAIR [J].

MRKSICH, M ;

DERVAN, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (07) :2572-2576

← 1 2 →