MAPPING OF A HUMAN BRAIN VOLTAGE-GATED CALCIUM-CHANNEL TO HUMAN CHROMOSOME-12P13-PTER

被引：14
|
作者：
SUN, W
MCPHERSON, JD
HOANG, DQ
WASMUTH, JJ
EVANS, GA
MONTAL, M
机构：
[1] UNIV CALIF SAN DIEGO,DEPT BIOL,LA JOLLA,CA 92093
[2] UNIV CALIF IRVINE,DEPT BIOL CHEM,IRVINE,CA 92717
[3] SALK INST BIOL STUDIES,MOLEC GENET LAB,SAN DIEGO,CA 92138
来源：
GENOMICS | 1992年 / 14卷 / 04期
关键词：
D O I：
10.1016/S0888-7543(05)80135-1
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Degenerate DNA oligomers coding for highly conserved regions of the voltage-gated calcium channel were synthesized for the polymerase chain reaction (PCR) using DNA from a human brain cDNA library as template. PCR amplified a 640-bp DNA fragment from the human brain cDNA library. Sequencing revealed that this fragment encodes part of a protein highly homologous to a subtype of the dihydropyridine-sensitive calcium channel cloned from rabbit heart and rat brain. Southern analysis of panels of somatic cell hybrids mapped the 640-bp fragment, CACNL1A1, to human chromosome 12p13-pter. © 1992 Academic Press, Inc. All rights reserved.
引用
收藏
页码：1092 / 1094
页数：3
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