Investigation of Total Oxidants/Antioxidants in Patients with Intracerebral Haemorrhage

被引:4
作者
Cevik, Mehmet Ugur [1 ]
Acar, Abdullah [1 ]
Yucel, Yavuz [1 ]
Varol, Sefer [1 ]
Akil, Esref [1 ]
Arikanoglu, Adalet [1 ]
Yuksel, Hatice [2 ]
机构
[1] Dicle Univ, Fac Med, Dept Neurol, Diyarbakir, Turkey
[2] Dicle Univ, Fac Med, Dept Biochem, Diyarbakir, Turkey
关键词
Oxidative stress; intracerebral hemorrhage; Glasgow Coma Scale;
D O I
10.4274/Tnd.77698
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Although there are numerous studies about oxidants and antioxidants in patients with ischemic stroke, the number of studies on this subject in patients with intracerebral hemorrhage (ICH) is limited. Malondialdehyde (MDA) is an oxidant parameter investigated in patients with ICH, and total oxidant status (TOS) has not been investigated so far. We aimed to investigate in blood samples the oxidant parameters MDA and TOS, and the total antioxidant status (TAS) in patients with ICH. Material and Method: A total of 30 patients with ICH, admitted and treated at the Neurology Clinic in the Faculty of Medicine, University of Dicle and 30 control who had no stroke or any systemic disorders were included in the study. Peripheral vein blood samples taken from patients and controls were included in the first 24 hours after stroke. Serum TAS, TOS values were measured with the Erel method, a specific, fully automatic and colorimetric method, and serum level of MDA was measured with method of Ohkawa. Results: Compared to the control group, the serum levels of TAS, TOS and MDA were significantly higher in the ICH patients (p < 0.05). However, there was no correlation between serum TOS, TAS and MDA levels and Glasgow Coma Scale (GCS) total scores and hematoma volumes (p> 0.05). Discussion: The increase in the serum levels of MDA, TOS, and TAS in ICH patients may demonstrate that there is an increase in oxidative stress and this supports the fact that that oxidative stress may play a significant role in the pathogenesis of the ICH. However, the increase of these parameters was not found to be associated with hematoma volume and GCS in patients with ICH.
引用
收藏
页码:1 / 4
页数:4
相关论文
共 18 条
  • [1] Serum C-reactive protein and lipid hydroperoxides in predicting short-term clinical outcome after spontaneous intracerebral hemorrhage
    Alexandrova, Margarita L.
    Danovska, Maya P.
    [J]. JOURNAL OF CLINICAL NEUROSCIENCE, 2011, 18 (02) : 247 - 252
  • [2] Plasma values of oxidants and antioxidants in acute brain hemorrhage - Role of free radicals in the development of brain injury
    Aygcul, R
    Demircan, B
    Erdem, F
    Ulvi, H
    Yildirim, A
    Demirbas, F
    [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 2005, 108 (1-3) : 43 - 52
  • [3] Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection
    Chen, Hai
    Yoshioka, Hideyuki
    Kim, Gab Seok
    Jung, Joo Eun
    Okami, Nobuya
    Sakata, Hiroyuki
    Maier, Carolina M.
    Narasimhan, Purnima
    Goeders, Christina E.
    Chan, Pak H.
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2011, 14 (08) : 1505 - 1517
  • [4] Chen HH, 2001, BIOMED ENVIRON SCI, V14, P189
  • [5] Clark JF, 2008, ACTA NEUROCHIR SUPPL, V105, P7
  • [6] A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation
    Erel, O
    [J]. CLINICAL BIOCHEMISTRY, 2004, 37 (04) : 277 - 285
  • [7] A new automated colorimetric method for measuring total oxidant status
    Erel, O
    [J]. CLINICAL BIOCHEMISTRY, 2005, 38 (12) : 1103 - 1111
  • [8] Hall NC, 2000, CELL MOL BIOL, V46, P673
  • [9] REACTIVE OXYGEN SPECIES AND THE CENTRAL-NERVOUS-SYSTEM
    HALLIWELL, B
    [J]. JOURNAL OF NEUROCHEMISTRY, 1992, 59 (05) : 1609 - 1623
  • [10] Hemoglobin-induced oxidative stress contributes to matrix metalloproteinase activation and blood-brain barrier dysfunction in vivo
    Katsu, Masataka
    Niizuma, Kuniyasu
    Yoshioka, Hideyuki
    Okami, Nobuya
    Sakata, Hiroyuki
    Chan, Pak H.
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2010, 30 (12) : 1939 - 1950