ON-CAPILLARY ISOTACHOPHORESIS FOR LOADABILITY ENHANCEMENT IN CAPILLARY ZONE ELECTROPHORESIS MASS-SPECTROMETRY OF BETA-AGONISTS

被引：62

作者：

LAMOREE, MH ^{[1
]}

REINHOUD, NJ ^{[1
]}

TJADEN, UR ^{[1
]}

NIESSEN, WMA ^{[1
]}

VANDERGREEF, J ^{[1
]}

机构：

[1] LEIDEN UNIV,LEIDEN AMSTERDAM CTR DRUG RES,DIV ANALYT CHEM,2300 RA LEIDEN,NETHERLANDS

来源：

BIOLOGICAL MASS SPECTROMETRY | 1994年 / 23卷 / 06期

关键词：

D O I：

10.1002/bms.1200230607

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

For the enhancement of sample loadability and concentration sensitivity in capillary zone electrophoresis/mass spectrometry (CZE/MS) on-line isotachophoresis/capillary zone electrophoresis (ITP/CZE) in a single capillary prior to mass spectrometric detection is described for clenbuterol and some analogues. Concentration detection limits were found to be in the nanogram per millilitre range. The applicability of ITP/CZE/MS as a trace analysis technique is demonstrated by the determination of some beta-agonists in calf urine.

引用

页码：339 / 345

页数：7

共 26 条

[1] ON-COLUMN SAMPLE CONCENTRATION USING FIELD AMPLIFICATION IN CZE [J].

CHIEN, RL ;

BURGI, DS .

ANALYTICAL CHEMISTRY, 1992, 64 (08) :A489-A496

[2] DETERMINATION OF CLENBUTEROL RESIDUES BY LIQUID-CHROMATOGRAPHY ELECTROSPRAY MASS-SPECTROMETRY [J].

DEBRAUWER, L ;

BORIES, G .

ANALYTICA CHIMICA ACTA, 1993, 275 (1-2) :231-239

[3]

DEBRAUWERL, 1993, CHROMATOGRAPHIA, V36, P218

[4]

EVERAERTS FM, 1976, ISOTACHOPHORESIS, V6

[5] ON-COLUMN TRANSIENT AND COUPLED COLUMN ISOTACHOPHORETIC PRECONCENTRATION OF PROTEIN SAMPLES IN CAPILLARY ZONE ELECTROPHORESIS [J].

FORET, F ;

SZOKO, E ;

KARGER, BL .

JOURNAL OF CHROMATOGRAPHY, 1992, 608 (1-2) :3-12

[6]

Foret F, 1990, J MICROCOLUMN SEP, V2, P229

[7] EFFECT OF ADDITION OF ORGANIC-SOLVENT ON THE SEPARATION OF POSITIONAL ISOMERS IN HIGH-VOLTAGE CAPILLARY ZONE ELECTROPHORESIS [J].

FUJIWARA, S ;

HONDA, S .

ANALYTICAL CHEMISTRY, 1987, 59 (03) :487-490

[8] RAPID-DETERMINATION OF CLENBUTEROL RESIDUES IN URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ONLINE AUTOMATED SAMPLE PROCESSING USING IMMUNOAFFINITY CHROMATOGRAPHY [J].

HAASNOOT, W ;

PLOUM, ME ;

PAULUSSEN, RJA ;

SCHILT, R ;

HUF, FA .

JOURNAL OF CHROMATOGRAPHY, 1990, 519 (02) :323-335

[9]

Harrison A. G., 1983, CHEM IONIZATION MASS

[10] ONLINE COUPLING OF CAPILLARY ISOTACHOPHORESIS WITH CAPILLARY ZONE ELECTROPHORESIS [J].

KANIANSKY, D ;

MARAK, J .

JOURNAL OF CHROMATOGRAPHY, 1990, 498 (01) :191-204

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