ANALYSIS OF THE MECHANISM OF CHLORAMPHENICOL ACETYLTRANSFERASE BY STEADY-STATE KINETICS - EVIDENCE FOR A TERNARY-COMPLEX MECHANISM

被引：69
作者：
KLEANTHOUS, C [1 ]
SHAW, WV [1 ]
机构：
[1] UNIV LEICESTER,DEPT BIOCHEM,LEICESTER LE1 7RH,ENGLAND
来源：
BIOCHEMICAL JOURNAL | 1984年 / 223卷 / 01期
关键词：
D O I：
10.1042/bj2230211
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：211 / 220
页数：10
相关论文
共 32 条
[1]   CATALYTIC SIGNIFICANCE OF BINARY ENZYME-ALDEHYDE COMPLEXES IN THE LIVER ALCOHOL-DEHYDROGENASE REACTION [J].
ANDERSSON, P ;
KVASSMAN, J ;
OLDEN, B ;
PETTERSSON, G .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1984, 139 (03) :519-527
[2]   RESISTANCE TO FUSIDIC ACID IN ESCHERICHIA-COLI MEDIATED BY THE TYPE-I VARIANT OF CHLORAMPHENICOL ACETYLTRANSFERASE - A PLASMID-ENCODED MECHANISM INVOLVING ANTIBIOTIC BINDING [J].
BENNETT, AD ;
SHAW, WV .
BIOCHEMICAL JOURNAL, 1983, 215 (01) :29-38
[3]   HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC ASSAY FOR CHLORAMPHENICOL, CHLORAMPHENICOL-3-MONOSUCCINATE, AND CHLORAMPHENICOL-1-MONOSUCCINATE [J].
BURKE, JT ;
WARGIN, WA ;
BLUM, MR .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1980, 69 (08) :909-912
[4]  
COLOWICK SP, 1969, J BIOL CHEM, V244, P774
[5]   KINETICS AND MECHANISM OF LIVER ALCOHOL DEHYDROGENASE WITH PRIMARY AND SECONDARY ALCOHOLS AS SUBSTRATES [J].
DALZIEL, K ;
DICKINSON, FM .
BIOCHEMICAL JOURNAL, 1966, 100 (01) :34-+
[6]   INITIAL STEADY STATE VELOCITIES IN THE EVALUATION OF ENZYME-COENZYME-SUBSTRATE REACTION MECHANISMS [J].
DALZIEL, K .
ACTA CHEMICA SCANDINAVICA, 1957, 11 (10) :1706-1723
[7]  
DELAFUEN.G, 1970, EUR J BIOCHEM, V16, P226
[8]   DIRECT LINEAR PLOT - NEW GRAPHICAL PROCEDURE FOR ESTIMATING ENZYME KINETIC-PARAMETERS [J].
EISENTHAL, R ;
CORNISH-BOWDEN, A .
BIOCHEMICAL JOURNAL, 1974, 139 (03) :715-720
[9]  
FERSHT A, 1977, ENZYME STRUCTURE MEC, P130
[10]  
FREY WH, 1977, J BIOL CHEM, V252, P51
1234