Primo Vessel as a Novel Cancer Cell Migration Path from Testis with Nanoparticle-Labeled and GFP Expressing Cancer Cells

被引：6

作者：

Han, Hyun-Jung ^{[1
]}

Kim, Hong-Bae ^{[1
]}

Cha, Jinmyung ^{[2
]}

Lee, Jin-Kyu ^{[2
]}

Youn, Hyewon ^{[3
]}

Chung, June-Key ^{[4
]}

Kim, Sungchul ^{[5
]}

Soh, Kwang-Sup ^{[1
]}

机构：

[1] Seoul Natl Univ, Adv Inst Convergence Technol, Nano Primo Res Ctr, Suwon, South Korea

[2] Seoul Natl Univ, Dept Chem, Mat Chem Lab, Seoul, South Korea

[3] Seoul Natl Univ Canc Hosp, Canc Imaging Ctr, Seoul, South Korea

[4] Seoul Natl Univ, Coll Med, Dept Nucl Med, Seoul, South Korea

[5] Wonkwang Univ Hosp, Dept Acupuncture & Moxibust, Gwangju, South Korea

来源：

JOURNAL OF ACUPUNCTURE AND MERIDIAN STUDIES | 2013年 / 6卷 / 06期

关键词：

cancer; metastasis; migration; nanoparticle;

D O I：

10.1016/j.jams.2013.09.003

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Background/aim: Recently, a novel circulatory system, the primo vascular system (PVS), was found to be a potent metastatic route of cancer cells. The aim of the current work is to demonstrate that cancer cells injected into the testis migrate through the primo vessel (PV). Materials and methods: NCI-H460 cells labeled with fluorescent nanoparticles (FNP) or green fluorescent protein (GFP) gene transfection were injected into testicular parenchyma in 24 rats. After 24 hours of injection, the abdominal cavity was investigated via a stereomicroscope, to detect the PVS, and the samples were analyzed histologically with 4',6-diamidino-2- phenylindole (DAPI) and hematoxylin and eosin.

引用

页码：298 / 305

页数：8

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