STRATIFICATION OF RODENT CARCINOGENICITY BIOASSAY RESULTS TO REFLECT RELATIVE HUMAN HAZARD

被引：75

作者：

TENNANT, RW

机构：

[1] Experimental Carcinogenesis and Mutagenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709

来源：

MUTATION RESEARCH | 1993年 / 286卷 / 01期

关键词：

RODENT BIOASSAY; TRANSSPECIES CARCINOGENS; GENETIC INFLUENCES; GENES AND CANCER; STRATIFICATION OF BIOASSAY RESULTS;

D O I：

10.1016/0027-5107(93)90006-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Trans-species, multiple site (particularly common site between species), mutagenic rodent carcinogens are less affected by the influences of polymorphic genes than are chemicals inducing more limited carcinogenic effects. Trans-species carcinogens, therefore, should represent a first priority for attention for human health risk.

引用

页码：111 / 118

页数：8

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