ANTITUMOR-ACTIVITY OF NEW ANTITUMOR SUBSTANCE, POLYOXOMOLYBDATE, AGAINST SEVERAL HUMAN CANCERS IN ATHYMIC NUDE-MICE

被引：35

作者：

FUJITA, H

FUJITA, T

SAKURAI, T

YAMASE, T

SETO, Y

机构：

[1] KEIO UNIV, SCH MED, INST PHARMACEUT, DIV CLIN CHEM, TOKYO 160, JAPAN

[2] TOKYO INST TECHNOL, RESOURCES UTILIZAT RES LAB, YOKOHAMA, KANAGAWA 227, JAPAN

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1992年 / 168卷 / 02期

关键词：

ANTITUMOR EFFECT; POLYOXOMOLYBDATE; HUMAN TUMOR; XENOGRAFT; NUDE MOUSE;

D O I：

10.1620/tjem.168.421

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antitumor polyoxomolybdates have been recognized in the course of study on the medical utilization of polyoxometalates, inorganic polymers of metal oxide. [NH3Pri]6[Mo7O24].3H2O (PM-8) was found as a representative of antitumor polyoxomolybdates. The growth suppressions of PM-8 against Co-4 human colon cancer xenografted under the subrenal capsule in cd-1 mice were equal or superior to that of 5-FU, MMC, ACNU, ADM and CDDP. Potent antitumor activity of PM-8 is also established against MX-1 human breast and OAT human lung cancer xenografted in athymic nude mice. Polyoxomolybdate is a new type of antitumor substance.

引用

页码：421 / 426

页数：6

共 10 条

[1]

FUJITA H, 1990, J CHEM IND CHEM, V5, P566

[2]

HARSTRICK A, 1989, CANCER, V63, P1079, DOI 10.1002/1097-0142(19890315)63:6<1079::AID-CNCR2820630607>3.0.CO

[3]

2-J

[4] PLATINUM COMPOUNDS - A NEW CLASS OF POTENT ANTITUMOUR AGENTS [J].

ROSENBERG, B ;

VANCAMP, L ;

TROSKO, JE ;

MANSOUR, VH .

NATURE, 1969, 222 (5191) :385-+

[5]

SAKURAI T, 1990, CHEMOTHERAPY, V38, P879

[6]

SAMSON MK, 1984, CANCER, V53, P1029, DOI 10.1002/1097-0142(19840301)53:5<1029::AID-CNCR2820530503>3.0.CO

[7]

2-Z

[8] MEDICAL CHEMISTRY OF POLYOXOMETALATES .2. ENZYMATIC STUDY ON BINDING OF HEPTAMOLYBDATE TO DNA [J].

TOMITA, K ;

YAMASE, T ;

SHISHIDO, K .

INORGANICA CHIMICA ACTA, 1989, 157 (02) :167-169

[9]

TOYOSHIMA S, 1985, RECENT ADV CANCER CH, V1, P945

[10] MEDICAL CHEMISTRY OF POLYOXOMETALATES .1. POTENT ANTITUMOR-ACTIVITY OF POLYOXOMOLYBDATES ON ANIMAL TRANSPLANTABLE TUMORS AND HUMAN CANCER XENOGRAFT [J].

YAMASE, T ;

FUJITA, H ;

FUKUSHIMA, K .

INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY, 1988, 151 (01) :15-18

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