DISULFIDE BRIDGES IN NH2-TERMINAL PART OF HUMAN FIBRINOGEN

被引：85

作者：

BLOMBACK, B ^{[1
]}

HESSEL, B ^{[1
]}

HOGG, D ^{[1
]}

机构：

[1] KAROLINSKA INST, DEPT BLOOD COAGULATION RES, S-10401 STOCKHOLM 60, SWEDEN

来源：

THROMBOSIS RESEARCH | 1976年 / 8卷 / 05期

关键词：

D O I：

10.1016/0049-3848(76)90245-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The NH2-terminal portion of fibrinogen (N-DSK) obtained by cleavage with CNBr was a dimeric structure (M.W. 58,000). The half-molecules of N-DSK were apparently held together by symmetrical disulfide bridges in its A.alpha.- and .gamma.-chains. Consequently the 2 half-molecules of fibrinogen were linked in the same way. In addition, N-DSK contained inter chain disulfide bridges within its half-molecules. The arrangement of these bridges was shown and the geometry in relation to function discussed.

引用

页码：639 / 658

页数：20

共 23 条

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