GENOTOXICITY OF THE FOOD MUTAGEN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE (PHIP) - FORMATION OF 2-HYDROXAMINO-PHIP, A DIRECTLY ACTING GENOTOXIC METABOLITE

被引:121
作者
HOLME, JA
WALLIN, H
BRUNBORG, G
SODERLUND, EJ
HONGSLO, JK
ALEXANDER, J
机构
关键词
D O I
10.1093/carcin/10.8.1389
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1389 / 1396
页数:8
相关论文
共 57 条
[1]   A CONVENIENT SYNTHESIS OF MUTAGENIC H-3-IMIDAZO[4,5-F]-QUINOLIN-2-AMINES AND THEIR 2-C-14 LABELED ANALOGS [J].
ADOLFSSON, L ;
OLSSON, K .
ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY, 1983, 37 (02) :157-159
[2]   4-(2-AMINO-1-METHYLIMIDAZO[4,5-B]PYRID-6-YL)PHENYL SULFATE - A MAJOR METABOLITE OF THE FOOD MUTAGEN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE (PHIP) IN THE RAT [J].
ALEXANDER, J ;
WALLIN, H ;
HOLME, JA ;
BECHER, G .
CARCINOGENESIS, 1989, 10 (08) :1543-1547
[3]  
ALTHAUS FR, 1982, CANCER RES, V42, P3010
[4]  
ALVES P, 1978, J CELL SCI, V32, P185
[5]   CANCER AND DIET - REPLY [J].
AMES, BN .
SCIENCE, 1984, 224 (4650) :668-&
[6]   METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST [J].
AMES, BN ;
MCCANN, J ;
YAMASAKI, E .
MUTATION RESEARCH, 1975, 31 (06) :347-363
[7]  
AMES BN, 1984, SCIENCE, V224, P757
[8]  
ANUFORO DC, 1978, IN VITRO CELL DEV B, V14, P981
[9]  
ASAN E, 1987, CARCINOGENESIS, V8, P1583
[10]  
BARNES WS, 1985, MUTAT RES, V156, P33