GLUCOSE-TOLERANCE AND INSULIN RELEASE, MATHEMATICAL APPROACH .1. ASSAY OF BETA-CELL RESPONSE AFTER ORAL GLUCOSE LOADING

被引：118

作者：

SLUITER, WJ ^{[1
]}

ERKELENS, DW ^{[1
]}

REITSMA, WD ^{[1
]}

DOORENBOS, H ^{[1
]}

机构：

[1] UNIV GRONINGEN, DEPT INTERN MED, DIV CLIN ENDOCRINOL, GRONINGEN, NETHERLANDS

来源：

DIABETES | 1976年 / 25卷 / 04期

关键词：

D O I：

10.2337/diabetes.25.4.241

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

From the dose-response relations in humans between glucose and insulin after oral glucose loading, a reproducible parameter for .beta.-cell response was deduced. The main advantage of this parameter, corrected insulin response defined as CIR = I .cntdot. 100/G(G-70) [G = glucose, in mg/100 ml; I = immunoreactive insulin in .mu.U[.mu.units]/ml], lies in its independence from the initial or reached glucose level.

引用

页码：241 / 244

页数：4

共 4 条

[1]

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[2] DECREASED SENSITIVITY OF PANCREATIC BETA CELLS TO GLUCOSE IN PREDIABETIC AND DIABETIC SUBJECTS - GLUCOSE DOSE-RESPONSE STUDY [J].

CERASI, E ;

EFENDIC, S ;

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DIABETES, 1972, 21 (04) :224-&

[3]

CONARD V, 1955, Acta Gastroenterol Belg, V18, P803

[4] INSULIN SECRETION IN RESPONSE TO GLYCEMIC STIMULUS - RELATION OF DELAYED INITIAL RELEASE TO CARBOHYDRATE INTOLERANCE IN MILD DIABETES MELLITUS [J].

SELTZER, HS ;

ALLEN, EW ;

HERRON, AL ;

BRENNAN, MT .

JOURNAL OF CLINICAL INVESTIGATION, 1967, 46 (03) :323-&

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