The Use of Bioinformatics for Studying HIV Evolutionary and Epidemiological History in South America

被引：11

作者：

Bello, Gonzalo ^{[1
,2
]}

Soares, Marcelo A. ^{[3
,4
]}

Schrago, Carlos G. ^{[3
]}

机构：

[1] Inst Oswaldo Cruz, Lab Imunol & Aids, BR-21040360 Rio De Janeiro, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Inst Microbiol, BR-21941590 Rio De Janeiro, RJ, Brazil

[3] Univ Fed Rio de Janeiro, Dept Genet, BR-21941902 Rio De Janeiro, RJ, Brazil

[4] Inst Nacl Canc, Programa Genet, BR-20231050 Rio De Janeiro, RJ, Brazil

来源：

AIDS RESEARCH AND TREATMENT | 2011年 / 2011卷

关键词：

D O I：

10.1155/2011/154945

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The South American human immunodeficiency virus type 1 (HIV-1) epidemic is driven by several subtypes (B, C, and F1) and circulating and unique recombinant forms derived from those subtypes. Those variants are heterogeneously distributed around the continent in a country-specific manner. Despite some inconsistencies mainly derived from sampling biases and analytical constrains, most of studies carried out in the area agreed in pointing out specificities in the evolutionary dynamics of the circulating HIV-1 lineages. In this paper, we covered the theoretical basis, and the application of bioinformatics methods to reconstruct the HIV spatial-temporal dynamics, unveiling relevant information to understand the origin, geographical dissemination and the current molecular scenario of the HIV epidemic in the continent, particularly in the countries of Southern Cone.

引用

页数：13

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