SYNTHESIS, ANTIBACTERIAL ACTIVITY AND MOLECULAR PROPERTIES PREDICTION OF SOME PYRIDAZIN-3-ONE DERIVATIVES

被引：9

作者：

Budhlakoti, Pankaj ^{[1
]}

Kumar, Y. ^{[1
]}

Verma, Amita ^{[2
]}

Alok, Shashi ^{[3
]}

机构：

[1] ITS, Dept Pharmaceut Chem, Ghaziabad, Uttar Pradesh, India

[2] Sam Higginbottom Inst Agr Technol & Sci, Fac Hlth Sci, Dept Pharmaceut Sci, Allahabad, Uttar Pradesh, India

[3] Bundelkhand Univ, Inst Pharm, Dept Pharmacognosy, Jhansi, Uttar Pradesh, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2013年 / 4卷 / 04期

关键词：

Pyridazine; antibacterial activity; disc diffusion method; Molinspiration;

D O I：

10.13040/IJPSR.0975-8232.4(4).1524-28

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have synthesized some new pyridazine-3-one derivatives and characterized by means of IR, NMR & mass spectral data. Compounds were evaluated for in-vitro antibacterial activity by disc diffusion method and further subjected to molecular properties prediction and drug-likeness by Molinspiration software. All compounds were found in compliance with Lipinski 'Rule of Five' and presented a good drug-likeness score with no violations. Compound I and IV having substitutent (6-phenyl, 6-chloro phenyl) has documented good antibacterial activity against S. aureus & S. epidermidis. Compound III & V (4'-chloro-benzylidine, 4'-methoxy-benzylidine) has reported good activity against P. aeruginosa & E. coli.

引用

页码：1524 / 1528

页数：5

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