An autopsy case of pulmonary fissure induced by zygomycosis

被引：4

作者：

Imai, Yuichiro ^{[1
]}

Adachi, Yasushi ^{[2
,3
]}

Kimura, Takashi ^{[4
]}

Nakano, Chikara ^{[5
]}

Shimizu, Toshiki ^{[4
]}

Shi, Ming ^{[2
]}

Okigaki, Mitsuhiko ^{[6
]}

Shimo, Tomohiko ^{[1
]}

Kaneko, Kazunari ^{[1
]}

Ikehara, Susumu ^{[2
]}

机构：

[1] Kansai Med Univ, Dept Pediat, Osaka, Japan

[2] Kansai Med Univ, Dept Stem Cell Disorders, 10-15 Fumizono Cho, Moriguchi, Osaka 5708506, Japan

[3] Toyooka Hosp, Div Clin Pathol, Toyooka, Hyogo, Japan

[4] Kansai Med Univ, Dept Internal Med 1, Osaka, Japan

[5] Kansai Med Univ, Dept Internal Med 2, Osaka, Japan

[6] Kyoto Prefectural Univ, Sch Med, Dept Cardiovasc Med, Kyoto, Japan

来源：

INTERNATIONAL JOURNAL OF GENERAL MEDICINE | 2013年 / 6卷

关键词：

pulmonary fissure; zygomycosis; aspergillosis; lung; immunosuppression;

D O I：

10.2147/IJGM.S44701

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

For immunodeficient patients, fungi are life-threatening pathogens. In this paper, we present an autopsy case of combined zygomycosis and aspergillosis. A female in her 70s on chronic hemodialysis was admitted to a hospital suffering bloody sputum, dyspnea, and fever, probably due to perinuclear anti-neutrophil cytoplasmic antibody-related vasculitis. Antibiotics were administered and immunosuppressive therapy was started, resulting in an improvement in her condition. Pneumonia later developed, followed by pulmonary bleeding and intractable pneumothorax from which she ultimately died. On autopsy, the upper lobe of the left lung was found to have hemorrhagic necrosis and showed a large longitudinal fissure. Microscopically, Zygomycota were observed in both the lungs and heart, while Aspergillus was found in the middle lobe of the right lung. Zygomycosis, which usually has a poor prognosis, is assumed to have induced hemorrhagic infarction of the lungs, inducing pulmonary bleeding and necrosis, despite the use of lipid formulations of amphotericin B, which are effective medicines against Zygomycota.

引用

页码：575 / 579

页数：5

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