ADENOSINE AND VENTRICULAR AUTOMATICITY

被引：4

作者：

HERNANDEZ, J ^{[1
]}

RIBEIRO, JA ^{[1
]}

机构：

[1] GULBENKIAN INST SCI,PHARMACOL LAB,P-2781 OEIRAS,PORTUGAL

来源：

LIFE SCIENCES | 1995年 / 57卷 / 15期

关键词：

ADENOSINE; VENTRICULAR AUTOMATICITY; CATECHOLAMINES; ADRENOCEPTORS;

D O I：

10.1016/0024-3205(95)02101-N

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Adenosine is considered a cardiodepressant agent due to its negative chronotropic and inotropic effects. However, the effect of adenosine on ventricular automaticity is less well established since both an increase and a decrease in ventricular automaticity have been reported. The experimental and clinical evidence dealing with the effects of adenosine on ventricular automaticity as well as the possible mechanisms involved, is presented in this review.

引用

页码：1393 / 1399

页数：7

共 44 条

[1]

BROODE OE, 1984, J CARDIOVASC PHARM, V6, P1184

[2] BINDING OF THE A1-SELECTIVE ADENOSINE ANTAGONIST 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE TO RAT-BRAIN MEMBRANES [J].

BRUNS, RF ;

FERGUS, JH ;

BADGER, EW ;

BRISTOL, JA ;

SANTAY, LA ;

HARTMAN, JD ;

HAYS, SJ ;

HUANG, CC .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1987, 335 (01) :59-63

[3] ADENOSINE AND SUPRAVENTRICULAR TACHYCARDIA [J].

CAMM, AJ ;

GARRATT, CJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (23) :1621-1629

[4]

DALY JW, 1983, CELL MOL NEUROBIOL, V1, P69

[5] ADENOSINE FOR PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA - DOSE RANGING AND COMPARISON WITH VERAPAMIL - ASSESSMENT IN PLACEBO-CONTROLLED, MULTICENTER TRIALS [J].

DIMARCO, JP ;

MILES, W ;

AKHTAR, M ;

MILSTEIN, S ;

SHARMA, AD ;

PLATIA, E ;

MCGOVERN, B ;

SCHEINMAN, MM ;

GOVIER, WC .

ANNALS OF INTERNAL MEDICINE, 1990, 113 (02) :104-110

[6] The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. [J].

Drury, AN ;

Szent-Gyorgyi, A .

JOURNAL OF PHYSIOLOGY-LONDON, 1929, 68 (03) :213-237

[7] ANTIARRHYTHMIC ACTIONS OF ADENOSINE IN THE EARLY STAGES OF EXPERIMENTAL MYOCARDIAL ISCHEMIA [J].

FAGBEMI, O ;

PARRATT, JR .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 100 (02) :243-244

[8] COMPARISON OF ADENOSINE AND VERAPAMIL FOR TERMINATION OF PAROXYSMAL JUNCTIONAL TACHYCARDIA [J].

GARRATT, C ;

LINKER, N ;

GRIFFITH, M ;

WARD, D ;

CAMM, AJ .

AMERICAN JOURNAL OF CARDIOLOGY, 1989, 64 (19) :1310-1316

[9] ADENOSINE-INDUCED TORSADES-DE-POINTES [J].

HARRINGTON, GR ;

FROELICH, EG .

CHEST, 1993, 103 (04) :1299-1301

[10] EVIDENCE FOR A COOPERATION BETWEEN ADENOSINE-A(2) RECEPTORS AND BETA(1)-ADRENOCEPTORS ON CARDIAC AUTOMATICITY IN THE ISOLATED RIGHT VENTRICLE OF THE RAT [J].

HERNANDEZ, J ;

PINTO, F ;

FIGUEIRA, MA ;

RIBEIRO, JA .

BRITISH JOURNAL OF PHARMACOLOGY, 1994, 111 (04) :1316-1320

← 1 2 3 4 5 →