ANALYSIS OF IN-VIVO IMMUNE-RESPONSES DURING TOXOPLASMA-GONDII INFECTION USING THE TECHNIQUE OF LYMPHATIC CANNULATION

A major obstacle in the design of effective inactivated vaccines is the induction of an appropriate immune response in the recipient Direct examination of immune responses induced in vivo following infection is possible using the technique of lymphatic cannulation. This allows a unique insight into the development of the immune response to Particular pathogens and provides important information that could be exploited in the design of suitable vaccine delivery systems in order to induce and maintain appropriate protective immune responses. In this article, Elisabeth Innes and Jonathan Wastling review studies involving the use of lymphatic cannulation to examine immune responses induced in vivo during infection of sheep with the S48 strain of Toxoplasma gondii, which is currently used as a vaccine against toxoplasmosis for veterinary use only.