Systemic thrombolysis and endovascular thrombectomy in severe acute ischemic stroke after dabigatran reversal with idarucizumab

被引：5

作者：

Binet, Quentin ^{[1
]}

Hammer, Frank D. ^{[2
]}

Rocrelle, Olivia ^{[3
]}

Peeters, Andre ^{[3
]}

Scavee, Christophe ^{[4
]}

Hermans, Cedric ^{[1
]}

机构：

[1] Clin Univ St Luc, Hemostasis & Thrombosis Unit, Div Adult Hematol, B-1200 Brussels, Belgium

[2] Clin Univ St Luc, Div Radiol, B-1200 Brussels, Belgium

[3] Clin Univ St Luc, Div Neurol, B-1200 Brussels, Belgium

[4] Clin Univ St Luc, Div Cardiol, B-1200 Brussels, Belgium

来源：

CLINICAL CASE REPORTS | 2018年 / 6卷 / 04期

关键词：

Acute ischemic stroke; dabigatran etexilate; idarucizumab; thrombectomy; thrombolysis;

D O I：

10.1002/ccr3.1446

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Key Clinical Message Patients presenting with an acute ischemic stroke despite dabigatran therapy (last intake <24 h or unknown) should be evaluated for reversal by idarucizumab, making them eligible for safe and effective intravenous thrombolysis. It has been shown to be feasible, well-tolerated, and easy to manage in an emergency room or stroke unit.

引用

页码：698 / 701

页数：4

共 7 条

[1] Intravenous thrombolysis for stroke in patients taking non-VKA oral anticoagulants: an update [J].

Cappellari, Manuel ;

Bovi, Paolo .

THROMBOSIS AND HAEMOSTASIS, 2015, 114 (02) :440-444

[2] Idarucizumab The Antidote for Reversal of Dabigatran [J].

Eikelboom, John W. ;

Quinlan, Daniel J. ;

van Ryn, Joanne ;

Weitz, Jeffrey I. .

CIRCULATION, 2015, 132 (25) :2412-2422

[3] Management of acute stroke in patients taking novel oral anticoagulants [J].

Hankey, Graeme J. ;

Norrving, Bo ;

Hacke, Werner ;

Steiner, Thorsten .

INTERNATIONAL JOURNAL OF STROKE, 2014, 9 (05) :627-632

[4] Updated European Heart Rhythm Association practical guide on the use of non-vitamin-K antagonist anticoagulants in patients with non-valvular atrial fibrillation: Executive summary [J].

Heidbuchel, Hein ;

Verhamme, Peter ;

Alings, Marco ;

Antz, Matthias ;

Diener, Hans-Christoph ;

Hacke, Werner ;

Oldgren, Jonas ;

Sinnaeve, Peter ;

Camm, A. John ;

Kirchhof, Paulus .

EUROPEAN HEART JOURNAL, 2017, 38 (27) :2137-2149

[5] Antagonizing dabigatran by idarucizumab in cases of ischemic stroke or intracranial hemorrhage in Germany - A national case collection [J].

Kermer, Pawel ;

Eschenfelder, Christoph C. ;

Diener, Hans-Christoph ;

Grond, Martin ;

Abdalla, Yasser ;

Althaus, Katharina ;

Berrouschot, Joerg ;

Canguer, Hakan ;

Daffertshofer, Michael ;

Edelbusch, Sebastian ;

Groeschel, Klaus ;

Haase, Claus G. ;

Harloff, Andreas ;

Held, Valentin ;

Kauert, Andreas ;

Kraft, Peter ;

Lenz, Arne ;

Muellges, Wolfgang ;

Obermann, Mark ;

Partowi, Someieh ;

Purrucker, Jan ;

Ringleb, Peter A. ;

Roether, Joachim ;

Rossi, Raluca ;

Schaefer, Niklas ;

Schneider, Andreas ;

Schuppner, Ramona ;

Seitz, Ruediger J. ;

Szabo, Kristina ;

Wruck, Robert .

INTERNATIONAL JOURNAL OF STROKE, 2017, 12 (04) :383-391

[6] Idarucizumab in Dabigatran-Treated Patients with Acute Ischemic Stroke Receiving Alteplase: A Systematic Review of the Available Evidence [J].

Pikija, Slaven ;

Sztriha, Laszlo K. ;

Mutzenbach, J. Sebastian ;

Golaszewski, Stefan M. ;

Sellner, Johann .

CNS DRUGS, 2017, 31 (09) :747-757

[7] Idarucizumab for the treatment of hemorrhage and dabigatran reversal in patients requiring urgent surgery or procedures [J].

Vornicu, Ovidiu ;

Larock, Anne-Sophie ;

Dincq, Anne-Sophie ;

Douxfils, Jonathan ;

Dogne, Jean-Michel ;

Mullier, Francois ;

Lessire, Sarah .

EXPERT OPINION ON BIOLOGICAL THERAPY, 2017, 17 (10) :1275-1296

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