INDUCTION OF TRANSCRIPTION FACTOR AP2 MESSENGER-RNA EXPRESSION IN RAT PRIMARY AFFERENT NEURONS DURING ACUTE-INFLAMMATION

被引：12

作者：

DONALDSON, LF

MCQUEEN, DS

SECKL, JR

机构：

[1] UNIV EDINBURGH, WESTERN GEN HOSP, DEPT MED, EDINBURGH EH4 2XU, MIDLOTHIAN, SCOTLAND

[2] UNIV EDINBURGH, DEPT PHARMACOL, EDINBURGH, MIDLOTHIAN, SCOTLAND

来源：

NEUROSCIENCE LETTERS | 1995年 / 196卷 / 03期

基金：

英国惠康基金;

关键词：

AP-2; MESSENGER-RNA; DORSAL ROOT GANGLION; NEUROPEPTIDE; IN SITU HYBRIDIZATION; INFLAMMATION; ADJUVANT ARTHRITIS;

D O I：

10.1016/0304-3940(95)11870-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have examined immediate early gene mRNA expression, using in situ hybridisation in innervating dorsal root ganglion (DRG) neurons following peripheral adjuvant injection. Neuronal expression of mRNAs encoding NGFI-A (nerve growth factor-induced), NGFI-B, c-jun, jun D and jun B was undetectable in untreated controls and was unchanged following adjuvant injection. AP-2 mRNA was expressed in the majority of DRG neurons in untreated controls and was significantly increased (217 +/- 43% control) 1 h after adjuvant injection. AP2 mRNA levels returned to control values by 2 h post-injection. AP-2 may form part of the early transcriptional response that induces neuropeptide gene expression in DRG after adjuvant injection.

引用

页码：181 / 184

页数：4

共 20 条

[1]

Carr, Nagy, Emerging relationships between cytochemical properties and sensory modality transmission in primary sensory neurons, Brain Res. Bull., 30, pp. 209-219, (1993)

[2]

Chapman, Lyons, Harmar, The sequence of 5′ flanking DNA from the rat preprotachykinin gene: analysis of putative transcription factor binding sites, Biochim. Biophys. Acta, 1172, pp. 361-363, (1993)

[3]

Courtois, Lafontaine, Lemaigre, Durviaux, Rousseau, Nuclear factor-I and activator protein-2 bind in a mutually exclusive way to overlapping promoter sequences and trans-activate the human growth hormone gene, Nucleic Acids Res., 18, pp. 57-64, (1990)

[4]

Donaldson, Harmar, McQueen, Seckl, Increased expression of preprotachykinin, calcitonin gene-related peptide, but not vasoactive intestinal peptide messenger RNA in dorsal root ganglia during the development of adjuvant monoarthritis in the rat, Mol. Brain Res., 16, pp. 143-149, (1992)

[5]

Donnerer, Schuligoi, Stein, Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: evidence for a regulatory function of nerve growth factor in vivo, Neuroscience, 49, 3, pp. 693-698, (1992)

[6]

Goodman, Regulation of neuropeptide gene expression, Annu. Rev. Neurosci., 13, pp. 111-127, (1990)

[7]

Henken, Tessler, Chesselet, Hudson, Baldino, Murray, In situ hybridization of mRNA for β-preprotachykinin and preprosomatostatin in adult rat dorsal root ganglia: comparison with immunocytochemical localization, J. Neurol., 17, pp. 671-681, (1988)

[8]

Herdegen, Fiallos-Estrada, Bravo, Zimmerman, Colocalisation and covariation of c-jun transcription factor with galanin in primary afferent neurons and with CGRP in spinal motoneurons following transection of rat sciatic nerves, Mol. Brain Res., 17, pp. 147-154, (1993)

[9]

Hunt, Pini, Evan, Induction of c-fos-like protein in spinal cord neurons following sensory stimulation, Nature, 328, pp. 632-634, (1987)

[10]

Iadarola, Draisci, Elevation of spinal cord dynorphin mRNA compared to dorsal root ganglion peptide mRNAs during peripheral inflammation, The Arthritic Rat as a Model of Clinical Pain?, pp. 173-183, (1988)

← 1 2 →