INDUCTION OF SURFACTIN PRODUCTION IN BACILLUS-SUBTILIS BY GSP, A GENE LOCATED UPSTREAM OF THE GRAMICIDIN-S OPERON IN BACILLUS-BREVIS

被引：40

作者：

BORCHERT, S ^{[1
]}

STACHELHAUS, T ^{[1
]}

MARAHIEL, MA ^{[1
]}

机构：

[1] UNIV MARBURG, FACHBEREICH CHEM BIOCHEM, D-35032 MARBURG, GERMANY

来源：

JOURNAL OF BACTERIOLOGY | 1994年 / 176卷 / 08期

关键词：

D O I：

10.1128/JB.176.8.2458-2462.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The deduced amino acid sequence of the gsp gene, located upstream of the 5' end of the gramicidin S operon (grs operon) in Bacillus brevis, showed a high degree of similarity to the sfp gene product, which is located downstream of the srfA operon in B. subtilis. The gsp gene complemented in trans a defect in the sfp gene (sfp(o)) and promoted production of the lipopeptide antibiotic surfactin. The functional homology of Gsp and Sfp and the sequence similarity of these two proteins to EntD suggest that the three proteins represent a new class of proteins involved in peptide secretion, in support of a hypothesis published previously (T. H. Grossman, M. Tuckman, S. Ellestad, and M. S. Osburne, J. Bacteriol. 175:6203-6211, 1993).

引用

页码：2458 / 2462

页数：5

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