REGULATION OF CELL-FUNCTION BY THE CELLULAR HYDRATION STATE

被引:233
作者
HAUSSINGER, D [1 ]
LANG, F [1 ]
GEROK, W [1 ]
机构
[1] UNIV TUBINGEN, INST PHYSIOL, D-72076 TUBINGEN, GERMANY
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1994年 / 267卷 / 03期
关键词
CELL VOLUME; PROTEIN TURNOVER; PROTEOLYSIS; BILE ACID SECRETION; HYPOSMOTIC; INSULIN; GLUCAGON; AMINO ACIDS; VESICULAR PH; METABOLIC REGULATION;
D O I
10.1152/ajpendo.1994.267.3.E343
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Cellular hydration can change within minutes under the influence of hormones, nutrients, and oxidative stress. Such short-term modulation of cell volume within a narrow range acts per se as a potent signal which modifies cellular metabolism and gene expression. It appears that cell swelling and cell shrinkage lead to certain opposite patterns of cellular metabolic function. Apparently, hormones and amino acids can trigger those patterns simply by altering cell volume. Thus alterations of cellular hydration may represent another important mechanism for metabolic control and act as another second or third messenger linking cell function to hormonal and environmental alterations.
引用
收藏
页码:E343 / E355
页数:13
相关论文
共 117 条
[1]  
AHLBERG J, 1985, J BIOL CHEM, V260, P5847
[2]   THE ROLE OF CELL SWELLING IN THE STIMULATION OF GLYCOGEN-SYNTHESIS BY INSULIN [J].
ALHABORI, M ;
PEAK, M ;
THOMAS, TH ;
AGIUS, L .
BIOCHEMICAL JOURNAL, 1992, 282 :789-796
[3]   CYTOSKELETAL ELEMENTS ARE REQUIRED FOR THE FORMATION AND MATURATION OF AUTOPHAGIC VACUOLES [J].
APLIN, A ;
JASIONOWSKI, T ;
TUTTLE, DL ;
LENK, SE ;
DUNN, WA .
JOURNAL OF CELLULAR PHYSIOLOGY, 1992, 152 (03) :458-466
[4]   POTASSIUM PERMEABILITY AND VOLUME CONTROL IN ISOLATED RAT HEPATOCYTES [J].
BAKKERGRUNWALD, T .
BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 731 (02) :239-242
[5]   COMPARISON OF THE EFFECTS OF VARIOUS AMINO-ACIDS ON GLYCOGEN-SYNTHESIS, LIPOGENESIS AND KETOGENESIS IN ISOLATED RAT HEPATOCYTES [J].
BAQUET, A ;
LAVOINNE, A ;
HUE, L .
BIOCHEMICAL JOURNAL, 1991, 273 :57-62
[6]   SWELLING OF RAT HEPATOCYTES ACTIVATES ACETYL-COA CARBOXYLASE IN PARALLEL TO GLYCOGEN-SYNTHASE [J].
BAQUET, A ;
MAISIN, L ;
HUE, L .
BIOCHEMICAL JOURNAL, 1991, 278 :887-890
[7]  
BAQUET A, 1990, J BIOL CHEM, V265, P955
[8]   HEPATOCYTE SWELLING INCREASES INOSITOL 1,4,5-TRISPHOSPHATE, CALCIUM AND CYCLIC-AMP CONCENTRATION BUT ANTAGONIZES PHOSPHORYLASE ACTIVATION BY CA-2+-DEPENDENT HORMONES [J].
BAQUET, A ;
MEIJER, AJ ;
HUE, L .
FEBS LETTERS, 1991, 278 (01) :103-106
[9]   MECHANISM OF ACTIVATION OF LIVER ACETYL-COA CARBOXYLASE BY CELL SWELLING [J].
BAQUET, A ;
GAUSSIN, V ;
BOLLEN, M ;
STALMANS, W ;
HUE, L .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 217 (03) :1083-1089
[10]   DEFECTIVE ACIDIFICATION OF INTRACELLULAR ORGANELLES IN CYSTIC-FIBROSIS [J].
BARASCH, J ;
KISS, B ;
PRINCE, A ;
SAIMAN, L ;
GRUENERT, D ;
ALAWQATI, Q .
NATURE, 1991, 352 (6330) :70-73