GOSSYPOL AND DERIVATIVES - A NEW CLASS OF ALDOSE REDUCTASE INHIBITORS

被引：47

作者：

DECK, LM ^{[1
]}

VANDERJAGT, DL ^{[1
]}

ROYER, RE ^{[1
]}

机构：

[1] UNIV NEW MEXICO,SCH MED,DEPT BIOCHEM,ALBUQUERQUE,NM 87131

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 11期

关键词：

D O I：

10.1021/jm00115a021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gossypol and 17 derivatives were tested as inhibitors of aldose reductase from human placenta. Gossypol and a number of the derivatives were potent inhibitors. The order of inhibitory activity was interpreted in relation to the Kador-Sharpless pharmacophor model for the aldose reductase inhibitor site. The structural but not the electronic aspects of the model were found to apply to this series of compounds.

引用

页码：3301 / 3305

页数：5

共 26 条

[1] Structure of gossypol VIII Derivatives of the ethers of gossypol
Adams, R
Geissman, TA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1938, 60 : 2166 - 2170
[2] Structure of gossypol VII Gossypol dimethyl ether
Adams, R
Geissman, TA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1938, 60 : 2163 - 2166
[3] COUNTERINTUITIVE ORBITAL MIXING IN SEMI-EMPIRICAL AND ABINITIO MOLECULAR-ORBITAL CALCULATIONS
AMMETER, JH
BURGI, HB
THIBEAULT, JC
HOFFMANN, R
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (12) : 3686 - 3692
[4] BAYNES JW, 1984, METHODS ENZYMOLOGY P, P88
[5] REVERSAL OF DIABETIC CATARACT BY SORBINIL, AN ALDOSE REDUCTASE INHIBITOR
BEYERMEARS, A
CRUZ, E
[J]. DIABETES, 1985, 34 (01) : 15 - 21
[6] CHRISTENSEN JEJ, 1985, ACTA NEUROL SCAND, V71, P164
[7] CHYLACK LT, 1979, OPHTHALMOLOGY, V86, P1579
[8] Clark EP, 1927, J BIOL CHEM, V75, P725
[9] COMPARATIVE STUDIES ON ALDOSE REDUCTASE FROM BOVINE, RAT AND HUMAN LENS
CONRAD, SM
DOUGHTY, CC
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1982, 708 (03) : 348 - 357
[10] CRABBE MJC, 1985, DIABETIC COMPLICATIO, P1

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