MOLECULAR ANALYSIS OF ACUTE PROMYELOCYTIC LEUKEMIA BREAKPOINT CLUSTER REGION ON CHROMOSOME-17

被引：624

作者：

BORROW, J ^{[1
]}

GODDARD, AD ^{[1
]}

SHEER, D ^{[1
]}

SOLOMON, E ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND,HUMAN CYTOGENET LAB,LONDON WC2A 3PX,ENGLAND

来源：

SCIENCE | 1990年 / 249卷 / 4976期

关键词：

D O I：

10.1126/science.2218500

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Acute promyelocytic leukemia (APL; FAB M3) is characterized by a predominance of malignant promyelocytes that carry a reciprocal translocation between the long arms of chromosomes 15 and 17, t(15;17)(q22;q11.2-q12). This translocation has become diagnostic for APL, as it is present in almost 100 percent of cases. A Not I linking clone was used to detect this translocation initially on pulsed-field gel electrophoresis and subsequently with conventional Southern (DNA) analysis. The breakpoints in ten APL cases examined were shown to cluster in a 12-kb region of chromosome 17, containing two CpG-rich islands. The region is the first intron of the retinoic acid receptor α gene (RARA).

引用

页码：1577 / 1580

页数：4

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