Novel Reagent for the Spectrophotometric Determination of Ranitidine Hydrochloride

被引：0

作者：

Narayana, Badiadka ^{[1
]}

Krishnamurthy, Ashwini ^{[1
]}

机构：

[1] Mangalore Univ, Dept Post Grad Studies & Res Chem, Mangalagangothri 574199, Karnataka, India

来源：

EURASIAN JOURNAL OF ANALYTICAL CHEMISTRY | 2010年 / 5卷 / 02期

关键词：

Ranitidine hydrochloride; Sodium periodate; Crystal violet;

D O I：

10.12973/ejac.2010.00094a

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple method is presented for the determination of ranitidine hydrochloride (RNH). The method is based on the reaction of RNH with sodium periodate in acidic medium to liberate iodine. The liberated iodine then bleaches the dye crystal violet (CV). The dye shows absorption maximum at 600 nm. The calibration graph is found to be linear over the range 400.00-500.00 mu g mL(-1). The molar absorptivity and sandell's sensitivity values are found to be 1.98x10(3) Lmol(-1)cm(-1) and 0.17 mu gcm(-2) respectively. The proposed method is compared with the earlier spectrophotometric methods for the determination of ranitidine hydrochloride. The method is successfully applied for the determination of ranitidine hydrochloride in pharmaceutical preparations.

引用

页码：170 / 176

页数：7

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