POSSIBLE ROLE OF ZINC IN THE SELECTIVE DEGENERATION OF DENTATE HILAR NEURONS AFTER CEREBRAL-ISCHEMIA IN THE ADULT-RAT

被引：234
作者：
TONDER, N
JOHANSEN, FF
FREDERICKSON, CJ
ZIMMER, J
DIEMER, NH
机构：
[1] UNIV COPENHAGEN,INST NEUROPATHOL,CEREBRAL ISCHEMIA RES GRP,PHARMABIOTEC,DK-1168 COPENHAGEN K,DENMARK
[2] UNIV TEXAS,NEUROBIOL LAB,RICHARDSON,TX 75080
来源：
NEUROSCIENCE LETTERS | 1990年 / 109卷 / 03期
关键词：
Excitotoxin; Fascia dentata; Glutamate; Hippocampus; Mossy fiber; Somatostatin; Toluene sulfonamide quinoline;
D O I：
10.1016/0304-3940(90)90002-Q
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The fluorescent dye 6-methoxy-8-p-toluene sulfonamide quinoline (TSQ) was used to monitor the distribution of zinc in the hippocampus and fascia dentata of adult rats subjected to 20 min of cerebral ischemia. In normal brains TSQ stains only neuropil, in particular the mossy fiber layers in the dentate hilus (CA4) and CA3, but within 2 h after ischemia, TSQ-fluorescent cells were observed in the dentate hilus. At longer survival times TSQ-positive cells stained positively with acid fuchsin, a sign of cellular degeneration. At the same time a decrease in the TSQ fluorescence of the mossy fiber terminals in the dentate hilus (CA4) and the CA3 mossy fiber layer was noted. The observations suggest that zinc many play a role in the selective death of dentate hilar neurons after cerebral ischemia. © 1990.
引用
收藏
页码：247 / 252
页数：6
相关论文
共 39 条
[1]   SELECTIVE RELEASE OF ENDOGENOUS ZINC FROM THE HIPPOCAMPAL MOSSY FIBERS INSITU [J].
ANIKSZTEJN, L ;
CHARTON, G ;
BENARI, Y .
BRAIN RESEARCH, 1987, 404 (1-2) :58-64
[2]   RELEASE OF ENDOGENOUS ZN-2+ FROM BRAIN-TISSUE DURING ACTIVITY [J].
ASSAF, SY ;
CHUNG, SH .
NATURE, 1984, 308 (5961) :734-736
[3]   ELEVATION OF THE EXTRACELLULAR CONCENTRATIONS OF GLUTAMATE AND ASPARTATE IN RAT HIPPOCAMPUS DURING TRANSIENT CEREBRAL-ISCHEMIA MONITORED BY INTRACEREBRAL MICRODIALYSIS [J].
BENVENISTE, H ;
DREJER, J ;
SCHOUSBOE, A ;
DIEMER, NH .
JOURNAL OF NEUROCHEMISTRY, 1984, 43 (05) :1369-1374
[4]  
BRUHN T, 1988, EUR J NEUROSCI S, P250
[5]   ZINC NEUROTOXICITY IN CORTICAL CELL-CULTURE [J].
CHOI, DW ;
YOKOYAMA, M ;
KOH, J .
NEUROSCIENCE, 1988, 24 (01) :67-79
[6]  
Coyle J. T., 1983, HDB CHEM NEUROANATOM, V1, P508
[7]   LOCALIZATION AND RELEASE OF GLUTAMIC-ACID IN RELATION TO HIPPOCAMPAL MOSSY FIBER PATHWAY [J].
CRAWFORD, IL ;
CONNOR, JD .
NATURE, 1973, 244 (5416) :442-443
[8]   CELLULAR-ORIGIN OF ISCHEMIA-INDUCED GLUTAMATE RELEASE FROM BRAIN-TISSUE INVIVO AND INVITRO [J].
DREJER, J ;
BENVENISTE, H ;
DIEMER, NH ;
SCHOUSBOE, A .
JOURNAL OF NEUROCHEMISTRY, 1985, 45 (01) :145-151
[9]   CYTOARCHITECTONIC DISTRIBUTION OF ZINC IN THE HIPPOCAMPUS OF MAN AND THE RAT [J].
FREDERICKSON, CJ ;
KLITENICK, MA ;
MANTON, WI ;
KIRKPATRICK, JB .
BRAIN RESEARCH, 1983, 273 (02) :335-339
[10]   A QUINOLINE FLUORESCENCE METHOD FOR VISUALIZING AND ASSAYING THE HISTOCHEMICALLY REACTIVE ZINC (BOUTON ZINC) IN THE BRAIN [J].
FREDERICKSON, CJ ;
KASARSKIS, EJ ;
RINGO, D ;
FREDERICKSON, RE .
JOURNAL OF NEUROSCIENCE METHODS, 1987, 20 (02) :91-103
1234