ERRATIC G-]A HYPERMUTATION WITHIN A COMPLETE CAPRINE ARTHRITIS-ENCEPHALITIS VIRUS (CAEV) PROVIRUS

被引：43
作者：
WAINHOBSON, S
SONIGO, P
GUYADER, M
GAZIT, A
HENRY, M
机构：
[1] INST COCHIN GENET MOLEC,CNRS,VPR 415,F-75014 PARIS,FRANCE
[2] CTR IMMUNOL,F-13288 MARSEILLE 9,FRANCE
[3] TEL AVIV UNIV,SACKLER SCH MED,DEPT HUMAN MICROBIOL,IL-69978 TEL AVIV,ISRAEL
来源：
VIROLOGY | 1995年 / 209卷 / 02期
关键词：
D O I：
10.1006/viro.1995.1261
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The complete nucleotide sequence of an integrated provirus of caprine arthritis-encephalitis virus (CAEV) has been determined. The provirus was defective due to extensive G --> A hypermutation. Rather than being a smooth phenomenon distributed throughout the genome it was highly erratic with hypermutated and normal regions being juxtaposed, probably reflecting local fluctuations in the intracellular dCTP pool during reverse transcription of the CAEV genome. The pattern of sequence Variation within the surface glycoproteins differs subtly from that of the primate lentiviruses. (C) 1995 Academic Press, Inc.
引用
收藏
页码：297 / 303
页数：7
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共 37 条
  • [1] GENETIC-VARIABILITY OF THE AIDS VIRUS - NUCLEOTIDE-SEQUENCE ANALYSIS OF 2 ISOLATES FROM AFRICAN PATIENTS
    ALIZON, M
    WAINHOBSON, S
    MONTAGNIER, L
    SONIGO, P
    [J]. CELL, 1986, 46 (01) : 63 - 74
  • [2] BEBENEK K, 1992, J BIOL CHEM, V267, P3589
  • [3] A HIGHLY DEFECTIVE HIV-1 GROUP-O PROVIRUS - EVIDENCE FOR THE ROLE OF LOCAL SEQUENCE DETERMINANTS IN G-]A HYPERMUTATION DURING NEGATIVE-STRAND VIRAL-DNA SYNTHESIS
    BORMAN, AM
    QUILLENT, C
    CHARNEAU, P
    KEAN, KM
    CLAVEL, F
    [J]. VIROLOGY, 1995, 208 (02) : 601 - 609
  • [4] ON THE MECHANISM OF DEOXYRIBONUCLEOSIDE TOXICITY IN HUMAN T-LYMPHOBLASTOID CELLS - REVERSAL OF GROWTH-INHIBITION BY ADDITION OF CYTIDINE
    DAHBO, Y
    ERIKSSON, S
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 150 (03): : 429 - 434
  • [5] GENETIC ORGANIZATION OF GIBBON APE LEUKEMIA-VIRUS
    DELASSUS, S
    SONIGO, P
    WAINHOBSON, S
    [J]. VIROLOGY, 1989, 173 (01) : 205 - 213
  • [6] DISTINCT SUBSETS OF RETROVIRUSES ENCODE DUTPASE
    ELDER, JH
    LERNER, DL
    HASSELKUSLIGHT, CS
    FONTENOT, DJ
    HUNTER, E
    LUCIW, PA
    MONTELARO, RC
    PHILLIPS, TR
    [J]. JOURNAL OF VIROLOGY, 1992, 66 (03) : 1791 - 1794
  • [7] FUNCTIONAL AND BIOLOGICAL PROPERTIES OF AN AVIAN VARIANT LONG TERMINAL REPEAT CONTAINING MULTIPLE A-CONVERSION TO G-CONVERSION IN THE U3 SEQUENCE
    FELDER, MP
    LAUGIER, D
    YATSULA, B
    DEZELEE, P
    CALOTHY, G
    MARX, M
    [J]. JOURNAL OF VIROLOGY, 1994, 68 (08) : 4759 - 4767
  • [8] GAO F, 1992, NATURE, V359, P495
  • [9] THE OPEN READING FRAME S OF VISNA VIRUS GENOME IS A TRANS-ACTIVATING GENE
    GOURDOU, I
    MAZARIN, V
    QUERAT, G
    SAUZE, N
    VIGNE, R
    [J]. VIROLOGY, 1989, 171 (01) : 170 - 178
  • [10] GENETIC CONSEQUENCES OF PACKAGING 2 RNA GENOMES IN ONE RETROVIRAL PARTICLE - PSEUDODIPLOIDY AND HIGH-RATE OF GENETIC-RECOMBINATION
    HU, WS
    TEMIN, HM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) : 1556 - 1560
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