EFFECT OF PULSATILE SHEAR-STRESS ON ENDOTHELIAL ATTACHMENT TO NATIVE VASCULAR SURFACES

被引：19
作者：
THOMPSON, MM
BUDD, JS
EADY, SL
JAMES, RFL
BELL, PRF
机构：
[1] Department of Surgery, Leicester Royal Infirmary, Leicester, LE2 7LX, Clinical Sciences Building
来源：
BRITISH JOURNAL OF SURGERY | 1994年 / 81卷 / 08期
基金：
英国惠康基金;
关键词：
D O I：
10.1002/bjs.1800810813
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
An in vitro model of vascular damage was used to investigate the ability of seeded endothelial cells to resist shear stresses generated in a perfusion circuit. At perfusion rates of 100 ml/min the maximum shear stress reached 16.5 dyn/cm(2). At this level the rate of cell detachment from the damaged vascular surface was 88 per cent per h for the first 20 min of flow but gradually decreased to 5 per cent per h after 90 min. These finding suggest that endothelial cells may be retained on damaged vascular surfaces in conditions that approximate to arterial flow.
引用
收藏
页码：1121 / 1127
页数：7
相关论文
共 44 条
  • [1] INFLUENCE OF ENDOTHELIAL-CELL SEEDING ON PLATELET DEPOSITION AND PATENCY IN SMALL-DIAMETER DACRON ARTERIAL GRAFTS
    ALLEN, BT
    LONG, JA
    CLARK, RE
    SICARD, GA
    HOPKINS, KT
    WELCH, MJ
    [J]. JOURNAL OF VASCULAR SURGERY, 1984, 1 (01) : 224 - 233
  • [2] ANDERSON JS, 1987, SURGERY, V101, P577
  • [3] BELDEN TA, 1982, T AM SOC ART INT ORG, V28, P173
  • [4] BLAND M, 1990, INTRO MED STATISTICS, P188
  • [5] Budd J S, 1991, Eur J Vasc Surg, V5, P397, DOI 10.1016/S0950-821X(05)80171-9
  • [6] EFFECTS OF 2 METHODS OF ENDOTHELIAL-CELL SEEDING ON CELL RETENTION DURING BLOOD-FLOW
    BUDD, JS
    ALLEN, KE
    BELL, PRF
    [J]. BRITISH JOURNAL OF SURGERY, 1991, 78 (07) : 878 - 882
  • [7] BUDD JS, 1991, SURGICAL RES COMMUNI, V11, P183
  • [8] BURKEL WE, 1981, J SURG RES, V30, P305, DOI 10.1016/0022-4804(81)90165-7
  • [9] CLOWES AW, 1991, J VASC SURG, V13, P885
  • [10] DEWEY CF, 1979, DYNAMICS ARTERIAL FL, P55
12345