TYPE-A CCK RECEPTORS MEDIATE THE INHIBITION OF FOOD-INTAKE AND ACTIVITY BY CCK-8 IN 9-DAY-OLD TO 12-DAY-OLD RAT PUPS

被引：49
作者：
SMITH, GP [1 ]
TYRKA, A [1 ]
GIBBS, J [1 ]
机构：
[1] CORNELL UNIV, COLL MED, DEPT PSYCHIAT, WHITE PLAINS, NY 10605 USA
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 38卷 / 01期
关键词：
ONTOGENY OF INGESTION; CCK ANTAGONISTS; L-365,260; MK-329;
D O I：
10.1016/0091-3057(91)90612-6
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
To determine the type of cholecystokinin (CCK) receptor that mediates the inhibitory effects of peripherally administered CCK-8 on food intake and activity in 9- to 12-day-old rat pups, we gave injection of a type-A CCK receptor antagonist, MK-329 , or of the type-B CCK receptor antagonist, L-365,260, prior to CCK-8 (IP). MK-329 reversed the inhibitory effects of CCK-8, but L-365,260 did not. This demonstrates that the inhibitory effects of CCk-8 (IP) are mediated by type-A, but not type-B, CCK receptors in pups of this age.
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页码：207 / 210
页数：4
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