STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS - ANALYSIS OF USE OF BINDING-ENERGY BY LINEAR FREE-ENERGY RELATIONSHIPS

被引：147
作者：
FERSHT, AR
LEATHERBARROW, RJ
WELLS, TNC
机构：
来源：
BIOCHEMISTRY | 1987年 / 26卷 / 19期
关键词：
D O I：
10.1021/bi00393a013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
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页码：6030 / 6038
页数：9
相关论文
共 17 条
[1]   EFFICIENCY AND EVOLUTION OF ENZYME CATALYSIS [J].
ALBERY, WJ ;
KNOWLES, JR .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1977, 16 (05) :285-293
[2]   CRYSTAL-STRUCTURES OF 2 FACTITIOUS MUTANTS OF TYROSYL-TRANSFER RNA-SYNTHETASE [J].
BROWN, KA ;
VRIELINK, A ;
BLOW, DM .
BIOCHEMICAL SOCIETY TRANSACTIONS, 1986, 14 (06) :1228-1229
[3]   PROBING STERIC AND HYDROPHOBIC EFFECTS ON ENZYME-SUBSTRATE INTERACTIONS BY PROTEIN ENGINEERING [J].
ESTELL, DA ;
GRAYCAR, TP ;
MILLER, JV ;
POWERS, DB ;
BURNIER, JP ;
NG, PG ;
WELLS, JA .
SCIENCE, 1986, 233 (4764) :659-663
[4]   HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING [J].
FERSHT, AR ;
SHI, JP ;
KNILLJONES, J ;
LOWE, DM ;
WILKINSON, AJ ;
BLOW, DM ;
BRICK, P ;
CARTER, P ;
WAYE, MMY ;
WINTER, G .
NATURE, 1985, 314 (6008) :235-238
[5]   QUANTITATIVE-ANALYSIS OF STRUCTURE-ACTIVITY-RELATIONSHIPS IN ENGINEERED PROTEINS BY LINEAR FREE-ENERGY RELATIONSHIPS [J].
FERSHT, AR ;
LEATHERBARROW, RJ ;
WELLS, TNC .
NATURE, 1986, 322 (6076) :284-286
[6]   BINDING-ENERGY AND CATALYSIS - A LESSON FROM PROTEIN ENGINEERING OF THE TYROSYL-TRANSFER RNA-SYNTHETASE [J].
FERSHT, AR ;
LEATHERBARROW, RJ ;
WELLS, TNC .
TRENDS IN BIOCHEMICAL SCIENCES, 1986, 11 (08) :321-325
[7]   ANALYSIS OF ENZYME STRUCTURE AND ACTIVITY BY PROTEIN ENGINEERING [J].
FERSHT, AR ;
SHI, JP ;
WILKINSON, AJ ;
BLOW, DM ;
CARTER, P ;
WAYE, MMY ;
WINTER, GP .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1984, 23 (07) :467-473
[8]  
FOSTER RJ, 1961, J BIOL CHEM, V236, P2461
[9]   INTERNAL THERMODYNAMICS OF POSITION 51 MUTANTS AND NATURAL VARIANTS OF TYROSYL-TRANSFER RNA-SYNTHETASE [J].
HO, CK ;
FERSHT, AR .
BIOCHEMISTRY, 1986, 25 (08) :1891-1897
[10]  
JENCKS WP, 1985, CHEM REV, V85, P511, DOI 10.1021/cr00070a001
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