SPECIFIC EXPRESSION OF HUMAN C-FGR IN NATURAL IMMUNITY EFFECTOR-CELLS

被引：33

作者：

INOUE, K ^{[1
]}

YAMAMOTO, T ^{[1
]}

TOYOSHIMA, K ^{[1
]}

机构：

[1] UNIV TOKYO,INST MED SCI,DEPT ONCOL,4-6-1 SHIROKANEDAI,MINATO KU,TOKYO 108,JAPAN

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 04期

关键词：

D O I：

10.1128/MCB.10.4.1789

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The c-fgr gene product was shown by immune complex protein kinase assay with specific antibodies to be a 58-kilodalton protein (p58(c-fgr)) with tyrosine-specific autophosphorylating activity. On examination of peripheral blood cells by immunoblotting with anti-c-fgr antibodies, p58(c-fgr) was found only in the fractions of monocytes, granulocytes, and natural killer cells. On the other hand, histochemical studies of hybridization demonstrated accumulation of c-fgr transcripts on most monocytes and large lymphocytes. In hematopoietic cell lines, p58(c-fgr) was detected in differentiated granulocytic cells as well as in differentiated monocytic cells of HL-60-cell origin. These data suggest a specific role for p58(c-fgr) in natural immunity effector cells.

引用

页码：1789 / 1792

页数：4

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