Changes in cochlear blood flow in mice due to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry

被引：15

作者：

Reif, Roberto ^{[1
]}

Zhi, Zhongwei ^{[1
]}

Dziennis, Suzan ^{[1
]}

Nuttall, Alfred L. ^{[2
]}

Wang, Ruikang K. ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, 3720 15th Ave NE, Seattle, WA 98195 USA

[2] Oregon Hlth & Sci Univ, Sch Med, Oregon Hearing Res Ctr, Portland, OR 97239 USA

来源：

QUANTITATIVE IMAGING IN MEDICINE AND SURGERY | 2013年 / 3卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Cochlear blood flow (CoBF); hypoxia; Doppler optical microangiography (DOMAG);

D O I：

10.3978/j.issn.2223-4292.2013.10.02

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In this work we determined the contributions of loud sound exposure (LSE) on cochlear blood flow (CoBF) in an in vivo anesthetized mouse model. A broadband noise system (20 kHz bandwidth) with an intensity of 119 dB SPL, was used for a period of one hour to produce a loud sound stimulus. Two techniques were used to study the changes in blood flow, a Doppler optical microangiography (DOMAG) system; which can measure the blood flow within individual cochlear vessels, and a laser Doppler flowmetry (LDF) system; which averages the blood flow within a volume (a hemisphere of similar to 1.5 mm radius) of tissue. Both systems determined that the blood flow within the cochlea is reduced due to the LSE stimulation.

引用

页码：235 / 242

页数：8

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