A CONCISE DIASTEREOSELECTIVE SYNTHESIS OF THE NATURAL (2R,3S)-2-HYDROXYMETHYL-3-HYDROXY-PYRROLIDINE

被引：59

作者：

GRIFFARTBRUNET, D ^{[1
]}

LANGLOIS, N ^{[1
]}

机构：

[1] INST CHIM SUBST NAT,CNRS,F-91190 GIF SUR YVETTE,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 01期

关键词：

PYROGLUTAMIC ACID; HYDROXYLATED PYRROLIDINE; EPOXIDATION; EPOXIDE OPENING; CASTANOSPERMUM;

D O I：

10.1016/0040-4039(94)88178-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(2R, 3S)-2-hydroxymethyl-3-hydroxy pyrrolidine 4, a constituent of Castanospermum australe.(1) was synthesized from (S)-pyroglutamic acid through diastereoselective epoxidation of alpha, beta-unsaturated pyrrolidone 8.

引用

页码：119 / 122

页数：4

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