A SIMPLE SYNTHESIS OF DELTA-2-OXAZOLINES, DELTA-2-OXAZINES, DELTA-2-THIAZOLINES AND 2-SUBSTITUTED BENZOXAZOLES

被引：194

作者：

VORBRUGGEN, H

KROLIKIEWICZ, K

机构：

[1] Research Laboratories, Schering AG

来源：

TETRAHEDRON | 1993年 / 49卷 / 41期

关键词：

D O I：

10.1016/0040-4020(93)80021-K

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Carboxylic acids react readily at 0-degrees --> +24-degrees-C with amino alcohols, amino mercaptans and o-aminophenols in the presence of triphenylphosphine- or tributylphosphine dichloride (generated in situ from the reaction of the phosphines with hexachloroethane or CCl4) and triethylamine in acetonitrile to form the corresponding DELTA2-oxazolines, DELTA2-oxazines, DELTA2-thiazolines and 2-substituted benzoxazoles in one reaction step in yields of up to 80%.

引用

页码：9353 / 9372

页数：20

共 70 条

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