EFFECTS OF L-STEPHOLIDINE ON TYROSINE-HYDROXYLASE ACTIVITY IN RAT CORPUS STRIATUM

被引：0

作者：

GUO, X ^{[1
]}

CHEN, LJ ^{[1
]}

BUDA, M ^{[1
]}

JIN, GZ ^{[1
]}

机构：

[1] CNRS,URA 1195,INSERM,U171,F-69373 LYONS,FRANCE

来源：

ACTA PHARMACOLOGICA SINICA | 1992年 / 13卷 / 04期

关键词：

L-STEPHOLIDINE; TYROSINE HYDROXYLASE; CORPUS STRIATUM; HALOPERIDOL; APOMORPHINE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

l-Stepholidine (SPD) 2.5 and haloperidol (Hal) 1.0 mg . kg-1 ip increased rat striatal L-3,4-dihydroxyphenylalanine (DOPA) and 3,4-dihydroxyphenylacetic acid (DOPAC) accumulation induced by NSD 1015 (50 mg . kg-1, ip), a decarboxylase inhibitor. SPD (2.5 mg . kg-1, ip) did not alter but apomorphine (2.0 mg . kg-1, ip) decreased the dopamine (DA) content elevated by gamma-butyrolactone (GBL, 750 mg . kg-1, ip) in the rat striatum. Ip injection of either SPD 5.0 or Hal 2.5 mg . kg-1 after NSD 1015 50 mg . kg-1 or NSD 1015 plus GBL 750 mg . kg-1 also augmented tyrosine hydroxylase (TH) activity in the rat striatum. These results suggest that SPD produces an antagonistic effect on presynaptic DA receptors.

引用

页码：289 / 292

页数：4

共 11 条

[1] PHARMACOLOGY OF DOPAMINE NEURONS INNERVATING THE PREFRONTAL, CINGULATE AND PIRIFORM CORTICES [J].