IDENTIFICATION OF METABOLITES DERIVED FROM THE H-2-RECEPTOR ANTAGONIST MIFENTIDINE USING TANDEM MASS-SPECTROMETRY

被引：16
作者：
KAJBAF, M [1 ]
LAMB, JH [1 ]
NAYLOR, S [1 ]
PATTICHIS, K [1 ]
GORROD, JW [1 ]
机构：
[1] UNIV LONDON,KINGS COLL,CHELSEA DEPT PHARM,LONDON SW3 6LX,ENGLAND
来源：
ANALYTICA CHIMICA ACTA | 1991年 / 247卷 / 02期
关键词：
MASS SPECTROMETRY; MIFENTIDINE;
D O I：
10.1016/S0003-2670(00)83810-6
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The in vitro metabolism of mifentidine, a second generation histamine H2-receptor antagonist, is investigated after hepatic microsomal incubation. By employing a combination of both daughter and parent ion scanning tandem mass spectrometry on synthetic standards and the microsomal incubate, it is revealed that mifentidine is metabolised to at least three compounds, namely the amine, formamide and urea metabolites. The detection and characterisation of the three metabolites is carried out with minimal sample purification.
引用
收藏
页码：151 / 159
页数：9
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