AN ENZYME LINKED IMMUNOASSAY FOR ANTI-MULLERIAN HORMONE - A NEW TOOL FOR THE EVALUATION OF TESTICULAR FUNCTION IN INFANTS AND CHILDREN

被引：111

作者：

JOSSO, N

LEGEAI, L

FOREST, MG

CHAUSSAIN, JL

BRAUNER, R

机构：

[1] HOP NECKER ENFANTS MALAD, INSERM, UNITE ENDOCRINOL PEDIAT, UNITE RECH ENDOCRINOL DEV, F-75743 PARIS 15, FRANCE

[2] HOP DEBROUSSE, INSERM, U34, UNITE RECH ENDOCRINOL & DEV ENFANT, F-69322 LYONS 05, FRANCE

[3] HOP ST VINCENT DE PAUL, SERV ENDOCRINOL PEDIAT, F-75674 PARIS 14, FRANCE

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1990年 / 70卷 / 01期

关键词：

D O I：

10.1210/jcem-70-1-23

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Anti-Müllerian hormone (AMH), also called Miillerian-inhibiting substance or factor was measured by an interspecific enzyme-linked immunoassay in the serum of 218 normal children and adults of both sexes and in 110 boys with various developmental disorders. AMH levels were high [81.67 ng/ml ± 7.44(SEM)] in normal males under 2 yr of age, fell progressively in older boys and, decreased sharply at puberty. Serum AMH was not detectable in adults or in females at any age, with very rare exceptions. AMH serum concentrations were significantly decreased in infants with disorders of sex differentiation, particularly testicular dysgenesis, and increased in patients with delayed puberty. In contrast, levels were not significantly affected by either cryptorchidism or chorionic gonadotropin stimulation. AMH shows promise as a marker of testicular function in infancy. © 1990 by The Endocrine Society.

引用

页码：23 / 27

页数：5

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