BERYLLIUM COORDINATION TO BIOLIGANDS - ISOLATION FROM AQUEOUS-SOLUTION AND CRYSTAL-STRUCTURE OF A HEXANUCLEAR COMPLEX OF BE2+ WITH GLYCOLIC ACID, NA4[BE6(OCH2CO2)8]

被引:26
作者
KUMBERGER, O [1 ]
RIEDE, J [1 ]
SCHMIDBAUR, H [1 ]
机构
[1] TECH UNIV MUNICH,INST ANORGAN CHEM,LICHTENBERGSTR 4,W-8046 GARCHING,GERMANY
来源
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 1992年 / 47卷 / 12期
关键词
BERYLLIUM COMPLEXES; BERYLLIUM GLYCOLATE COMPLEX; BIOLIGAND COMPLEXATION OF BERYLLIUM; BERYLLIUM TOXICITY;
D O I
10.1515/znb-1992-1212
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Beryllium and its compounds are highly toxic to most living cells, but the mechanisms of the interference with the biological substrates on the molecular level is not understood. From observations in (attempted) chemotherapy of beryllium poisoning using a variety of complexing agents it has been concluded that Be2+ is interacting predominantly with carboxyl as well as hydroxyl functions of protein bio-polymers, with complete deprotonation of the alkoxy or phenoxy functions involved. As a first support for this hypothesis, an analytically well-defined beryllium complex of glycolic acid has now been isolated from aqueous solutions under near-physiological conditions, crystallized and its structure determined by X-ray diffraction. The hexanuclear complex features beryllium in two different environments, mono- and bis-chelated by glycolate ligands with deprotonated hydroxyl groups. In Be-9-NMR studies of aqueous solutions of the complex (pH 6) the persistence of complexation in two different environments of Be2+ could also be confirmed. The new structure may serve as a model for beryllium complexation with larger bio-ligands.
引用
收藏
页码:1717 / 1720
页数:4
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