ENZYMATIC AND CHEMICAL SYNTHESES OF CIS-DIHYDRODIOL DERIVATIVES OF MONOCYCLIC ARENES

被引:44
作者
BOYD, DR
HAND, MV
SHARMA, ND
CHIMA, J
DALTON, H
SHELDRAKE, GN
机构
[1] UNIV WARWICK,DEPT BIOL SCI,COVENTRY CV4 7AL,W MIDLANDS,ENGLAND
[2] ICI PLC,FINE CHEM MFG ORG,HUDDERSFIELD HD2 1FF,YORKS,ENGLAND
关键词
D O I
10.1039/c39910001630
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Metabolism of bromobenzene and iodobenzene by growing cultures of Pseudomonas putida UV4 gave the corresponding cis-dihydrodiol products 1 and 2 in high yields; subsequent direct chemical substitution of the halogen atoms in these metabolites provided a new range of enantiomerically pure cis-dihydrodiols of known absolute configuration.
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页码:1630 / 1632
页数:3
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