CLONING OF THE GENE ENCODING STREPTOCOCCIN A-FF22, A NOVEL LANTIBIOTIC PRODUCED BY STREPTOCOCCUS-PYOGENES, AND DETERMINATION OF ITS NUCLEOTIDE-SEQUENCE

被引：62

作者：

HYNES, WL ^{[1
]}

FERRETTI, JJ ^{[1
]}

TAGG, JR ^{[1
]}

机构：

[1] UNIV OTAGO,DEPT MICROBIOL,DUNEDIN,NEW ZEALAND

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 1993年 / 59卷 / 06期

关键词：

D O I：

10.1128/AEM.59.6.1969-1971.1993

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptococcin A-FF22 (SA-FF22) is a lantibiotic produced by Streptococcus pyogenes FF22. The nucleotide sequence of the SA-FF22 structural gene (scnA) was determined and shown to encode a 51-amino-acid prepeptide. The proteolytic processing site of the SA-FF22 prepeptide differs from that which characterizes other type A lantibiotics.

引用

收藏

页码：1969 / 1971

页数：3

相关论文

共 13 条

[1] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].

DEVEREUX, J ;

HAEBERLI, P ;

SMITHIES, O .

NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395

[2] HETEROGENEITY OF THE STREPTOKINASE GENE IN GROUP-A STREPTOCOCCI [J].

HUANG, TT ;

MALKE, H ;

FERRETTI, JJ .

INFECTION AND IMMUNITY, 1989, 57 (02) :502-506

[3]

HYNES WL, 1992, FEMS MICROBIOL LETT, V94, P139

[4]

JACK RW, 1991, NISIN NOVEL LANTIBIO, P171

[5] LANTIBIOTICS - RIBOSOMALLY SYNTHESIZED BIOLOGICALLY-ACTIVE POLYPEPTIDES CONTAINING SULFIDE BRIDGES AND ALPHA-BETA-DIDEHYDROAMINO ACIDS [J].

JUNG, G .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1991, 30 (09) :1051-1068

[6] NISIN, A PEPTIDE ANTIBIOTIC - CLONING AND SEQUENCING OF THE NISA GENE AND POSTTRANSLATIONAL PROCESSING OF ITS PEPTIDE PRODUCT [J].

KALETTA, C ;

ENTIAN, KD .

JOURNAL OF BACTERIOLOGY, 1989, 171 (03) :1597-1601

[7] ANALYSIS OF GENES INVOLVED IN BIOSYNTHESIS OF THE LANTIBIOTIC SUBTILIN [J].

KLEIN, C ;

KALETTA, C ;

SCHNELL, N ;

ENTIAN, KD .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1992, 58 (01) :132-142

[8] CODON USAGE IN STREPTOCOCCI [J].

MALKE, H .

JOURNAL OF BASIC MICROBIOLOGY, 1986, 26 (10) :587-595

[9] PREPEPTIDE SEQUENCE OF EPIDERMIN, A RIBOSOMALLY SYNTHESIZED ANTIBIOTIC WITH 4 SULFIDE-RINGS [J].

SCHNELL, N ;

ENTIAN, KD ;

SCHNEIDER, U ;

GOTZ, F ;

ZAHNER, H ;

KELLNER, R ;

JUNG, G .

NATURE, 1988, 333 (6170) :276-278

[10] BACTERIOCINE PRODUCTION BY GROUP-A STREPTOCOCCI [J].

TAGG, JR ;

READ, RSD ;

MCGIVEN, AR .

PATHOLOGY, 1971, 3 (04) :277-&