FC-RECEPTORS DO NOT MEDIATE AFRICAN SWINE FEVER VIRUS-REPLICATION IN MACROPHAGES

被引：12

作者：

ALCAMI, A ^{[1
]}

VINUELA, E ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID,FAC CIENCIAS,CTR BIOL MOLEC,CANTO BLANCO,E-28049 MADRID,SPAIN

来源：

VIROLOGY | 1991年 / 181卷 / 02期

关键词：

D O I：

10.1016/0042-6822(91)90912-U

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Titration experiments in swine macrophages have shown that African swine fever virus infectivity was not enhanced in the presence of antiviral antibodies. The early viral protein synthesis and the viral DNA replication in swine macrophages infected with virus-antibody complexes were inhibited in the presence of high doses of uv-inactivated virus, which saturated specific virus receptors, but not when Fc receptors were saturated with antibodies. These results indicate that African swine fever virus does not infect swine macrophages through Fc receptors and that the normal entry pathway through virus receptors is not bypassed by the virus-antibody complexes. © 1991.

引用

页码：756 / 759

页数：4

共 37 条

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