6-[F-18]FLUORO-L-DOPA METABOLISM IN MPTP-TREATED MONKEYS - ASSESSMENT OF TRACER METHODOLOGIES FOR POSITRON EMISSION TOMOGRAPHY

被引：34

作者：

MELEGA, WP

HOFFMAN, JM

SCHNEIDER, JS

PHELPS, ME

BARRIO, JR

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT RADIOL SCI,DIV NUCL MED & BIOPHYS,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,NUCL MED LAB,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,SCH MED,DEPT PHARMACOL,LOS ANGELES,CA 90024

来源：

BRAIN RESEARCH | 1991年 / 543卷 / 02期

关键词：

L-3,4-DIHYDROXY-6-[F-18]FLUOROPHENYLALANINE; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; DOPAMINE METABOLISM; PARKINSONS DISEASE; MONKEY BRAIN;

D O I：

10.1016/0006-8993(91)90037-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

6-[F-18]Fluoro-L-DOPA (FDOPA) is an L-DOPA analog that is used to assess the functional integrity of central dopaminergic systems in vivo with positron emission tomography (PET). FDOPA metabolites from putamen of normal and MPTP-treated monkeys were characterized to correlate FDOPA metabolism changes with those of the endogenous dopamine system. In MPTP-lesioned putamen, 6-[F-18]fluorodopamine and dopamine levels were less than 2% those of controls. Increases in endogenous dopamine metabolism were reflected by similar increases in 6-[F-18]fluorodopamine metabolites. These results suggest that changes in the central dopamine system biochemistry can be monitored in vivo with FDOPA and PET.

引用

页码：271 / 276

页数：6

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