DNA Methylation in Neurodegenerative Disorders

被引：0

作者：

Xu, Zihui ^{[1
,2
]}

Xuekun Li ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Anat, Div Histol & Embryol, Wuhan, Hubei, Peoples R China

来源：

CURRENT GERIATRICS REPORTS | 2012年 / 1卷 / 04期

关键词：

DNA methylation; Neurodegeneration; Cognitive function; Aging; Alzheimer's disease; Parkinson's disease; Amyotrophic lateral sclerosis; DNA demethylation;

D O I：

10.1007/s13670-012-0026-1

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Epigenetic mechanisms are essential in a host of biological processes and many different human diseases. Epigenetic modifications include DNA methylation, histone modification, non-coding RNA, and nucleosome positioning. In neuronal systems, extensive studies have revealed important regulatory roles of DNA methylation in brain function, from the embryonic stage through the process of aging. Here we review recent evidence that DNA methylation is involved in aging, learning and memory, and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and CGG repeat-induced neurodegenerative disorders. We also explore the dynamics of DNA methylation.

引用

页码：199 / 205

页数：7

共 71 条

[1] Gene regulation by nucleosome positioning [J].

Bai, Lu ;

Morozov, Alexandre V. .

TRENDS IN GENETICS, 2010, 26 (11) :476-483

[2] Alzheimer's disease [J].

Blennow, Kaj ;

de Leon, Mony J. ;

Zetterberg, Henrik .

LANCET, 2006, 368 (9533) :387-403

[3] Decline in genomic DNA methylation through aging in a cohort of elderly subjects [J].

Bollati, Valentina ;

Schwartz, Joel ;

Wright, Robert ;

Litonjua, Augusto ;

Tarantini, Letizia ;

Suh, Helen ;

Sparrow, David ;

Vokonas, Pantel ;

Baccarelli, Andrea .

MECHANISMS OF AGEING AND DEVELOPMENT, 2009, 130 (04) :234-239

[4] Dnmt3L and the establishment of maternal genomic imprints [J].

Bourc'his, D ;

Xu, GL ;

Lin, CS ;

Bollman, B ;

Bestor, TH .

SCIENCE, 2001, 294 (5551) :2536-2539

[5] Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts [J].

Casillas, MA ;

Lopatina, N ;

Andrews, LG ;

Tollefsbol, TO .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2003, 252 (1-2) :33-43

[6] α-synuclein locus duplication as a cause of familial Parkinson's disease [J].

Chartier-Harlin, MC ;

Kachergus, J ;

Roumier, C ;

Mouroux, V ;

Douay, X ;

Lincoln, S ;

Levecque, C ;

Larvor, L ;

Andrieux, J ;

Hulihan, M ;

Waucquier, N ;

Defebvre, L ;

Amouyel, P ;

Farrer, M ;

Destée, A .

LANCET, 2004, 364 (9440) :1167-1169

[7] Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family [J].

Chen, ZX ;

Mann, JR ;

Hsieh, CL ;

Riggs, AD ;

Chédin, F .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2005, 95 (05) :902-917

[8] Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation [J].

Chestnut, Barry A. ;

Chang, Qing ;

Price, Ann ;

Lesuisse, Catherine ;

Wong, Margaret ;

Martin, Lee J. .

JOURNAL OF NEUROSCIENCE, 2011, 31 (46) :16619-16636

[9] Epigenetic regulation in the pathophysiology of Alzheimer's disease [J].

Chouliaras, Leonidas ;

Rutten, Bart P. F. ;

Kenis, Gunter ;

Peerbooms, Odette ;

Visser, Pieter Jelle ;

Verhey, Frans ;

van Os, Jim ;

Steinbusch, Harry W. M. ;

van den Hove, Daniel L. A. .

PROGRESS IN NEUROBIOLOGY, 2010, 90 (04) :498-510

[10] The contribution of cis-elements to disease-associated repeat instability:: clinical and experimental evidence [J].

Cleary, JD ;

Pearson, CE .

CYTOGENETIC AND GENOME RESEARCH, 2003, 100 (1-4) :25-55

← 1 2 3 4 5 6 7 8 →