Transcriptome analysis of Rpl11-deficient zebrafish model of Diamond-Blackfan Anemia

被引：4

作者：

Zhang, Zhaojun ^{[1
]}

Jia, Haibo ^{[2
]}

Zhang, Qian ^{[1
]}

Wan, Yang ^{[3
,4
,5
]}

Song, Binfeng ^{[2
]}

Jia, Qiong ^{[2
]}

Liu, Hanzhi ^{[3
,4
,5
]}

Zhu, Xiaofan ^{[3
,4
,5
]}

Fang, Xiangdong ^{[1
]}

机构：

[1] Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China

[2] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Ctr Human Genome Res, Key Lab Mol Biophys,Minist Educ, Wuhan 430074, Hubei, Peoples R China

[3] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China

[4] Chinese Acad Med Sci, Blood Dis Hosp, Tianjin 300020, Peoples R China

[5] Peking Union Med Coll, Tianjin 300020, Peoples R China

来源：

GENOMICS DATA | 2014年 / 2卷

基金：

中国国家自然科学基金;

关键词：

Transcriptome; Zebrafish; DBA; High-Seq; 2000; IPA;

D O I：

10.1016/j.gdata.2014.06.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To comprehensively reflect the roles of Rpl11 on the transcriptome of zebrafish model of Diamond-Blackfan Anemia ( DBA), we performed whole-genome transcriptome sequencing on the Illumina Hi-Seq 2000 sequencing platform. Two different transcriptomes of zebrafish Rpl11-deficient and control Morpholino (Mo) embryos were collected and analyzed. The experimental design and methods, including sample preparation, RNA-Seq data evaluation and treatment, were described in details so that representative high-throughput sequencing data were acquired for assessing the actual impacts of Rpl11 on zebrafish embryos. We provided the accession number GSE51326 for easy access to the database. (C) 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.

引用

页码：173 / 175

页数：3

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