HIGH-CONCENTRATION OF A GASTRIN RELEASING PEPTIDE-LIKE IMMUNOREACTIVE SUBSTANCE IN PREGNANT HUMAN-MILK

被引：12

作者：

TAKEYAMA, M ^{[1
]}

KONDO, K ^{[1
]}

TAKAYAMA, F ^{[1
]}

KONDO, R ^{[1
]}

MURATA, H ^{[1
]}

MIYAKAWA, I ^{[1
]}

机构：

[1] MED COLL OITA,DEPT OBSTET & GYNECOL,HASAMA,OITA 87955,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 02期

关键词：

D O I：

10.1016/S0006-291X(05)80275-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The level of a gastrin releasing peptide-like immunoreactive substance (GRP-IS) in human milk and plasma during late pregnancy and after delivery was measured. GRP-IS in milk increased during late pregnancy (1.3 nM at 39 weeks) and decreased after delivery (100 pM). GRP-IS in plasma during late pregnancy and after delivery was much lower (below 2 pM). By using HPLC and gel-filtration chromatography, two peaks of GRP-IS were purified. The one was coeluted with GRP(18-27) and the other was a prohormone. The GRP-IS in milk during pregnancy was mostly composed of proGRP. These results suggest that GRP may be produced and secreted in mammary glands. © 1991 Academic Press, Inc.

引用

页码：931 / 937

页数：7

共 21 条

[1]

AMARANT T, 1982, EUR J BIOCHEM, V127, P647, DOI 10.1111/j.1432-1033.1982.tb06921.x

[2] ISOLATION AND STRUCTURE OF BOMBESIN AND ALYTESIN, 2 ANALOGOUS ACTIVE PEPTIDES FROM SKIN OF EUROPEAN AMPHIBIANS BOMBINA AND ALYTES [J].

ANASTASI, A ;

ERSPAMER, V ;

BUCCI, M .

EXPERIENTIA, 1971, 27 (02) :166-&

[3] BOMBESIN-LIKE PEPTIDES CAN FUNCTION AS AUTOCRINE GROWTH-FACTORS IN HUMAN SMALL-CELL LUNG-CANCER [J].

CUTTITTA, F ;

CARNEY, DN ;

MULSHINE, J ;

MOODY, TW ;

FEDORKO, J ;

FISCHLER, A ;

MINNA, JD .

NATURE, 1985, 316 (6031) :823-826

[4]

HIRATA Y, 1983, FOLIA ENDOCRINOL, V59, P1930

[5] A BOMBESIN IMMUNOREACTIVE PEPTIDE IN MILK [J].

JAHNKE, GD ;

LAZARUS, LH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (02) :578-582

[6] REGULATION OF ANTRAL GASTRIN CONTENT [J].

JOHNSON, LR ;

GUTHRIE, PD .

AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 245 (06) :G725-G729

[7]

LEHY T, 1983, GASTROENTEROLOGY, V84, P914

[8] GASTRIN RELEASING PEPTIDE FROM PORCINE NON-ANTRAL GASTRIC TISSUE [J].

MCDONALD, TJ ;

NILSSON, G ;

VAGNE, M ;

GHATEI, M ;

BLOOM, SR ;

MUTT, V .

GUT, 1978, 19 (09) :767-774

[9]

McDonald TJ, 1981, GUT HORM, P407

[10] BOMBESIN INGESTION STIMULATES EPITHELIAL DIGESTIVE CELL-PROLIFERATION IN SUCKLING RATS [J].

PUCCIO, F ;

LEHY, T .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (02) :G328-G334

← 1 2 3 →