DERIVATIVES OF DIHYDROPYRIMIDO (4,5-B) (1,4) BENZOTHIAZINE AND THEIR PHARMACOLOGICAL PROPERTIES

被引:0
|
作者
POLEZHAEVA, AI
ROSHCHINA, LF
SOKOLOVA, AS
NEMERYUK, MP
PYKHOVA, MV
SAFONOVA, TS
MASHKOVSKY, MD
机构
来源
KHIMIKO-FARMATSEVTICHESKII ZHURNAL | 1981年 / 15卷 / 11期
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
7,7-Dimethyl-9-amino-6H-7,8-dihydropyrimido(4,5-b)(1,4)-benzothiazine HBr derivatives were synthesized. Experiments in mice and rats showed that some compounds possessed neurotropic, neuroleptic and antidepressive activities of differing degrees. These compounds were less active than the known tricyclic antidepressants and neuroleptics.
引用
收藏
页码:45 / 50
页数:6
相关论文
共 50 条
  • [1] ALGORITHMIC SEARCH FOR FOLIC-ACID ANTAGONISTS AMONG THE DERIVATIVES OF PYRIMIDO[4,5-B](1,4)BENZOTHIAZINE
    TYURINA, LA
    SEMENOV, VA
    NEMERYUK, MP
    RYABOKON, NA
    CHERNOV, VA
    SAFONOVA, TS
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1985, 19 (09): : 1080 - 1086
  • [2] Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors
    Bakavoli, M.
    Nikpour, M.
    Rahimizadeh, M.
    Saberi, M. R.
    Sadeghian, H.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (05) : 2120 - 2126
  • [3] SYNTHESIS AND BIOLOGICAL PROPERTIES OF PYRIMIDO[4,5-B]-[1,4]THIAZINE
    SOKOLOVA, AS
    RYABOKON, NA
    ERSHOVA, YA
    ANDREEVA, NA
    NEMERYUK, MP
    KEREMOV, AF
    TRAVEN, NI
    YADROVSKAYA, VA
    CHERNOV, VA
    SAFONOVA, TS
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1977, 11 (09): : 49 - 54
  • [4] SAR comparative studies on pyrimido[4,5-b][1,4] benzothiazine derivatives as 15-lipoxygenase inhibitors, using ab initio calculations
    Bakavoli, Mehdi
    Sadeghian, Hamid
    Tabatabaei, Zahra
    Rezaei, Elham
    Rahimizadeh, Mohammad
    Nikpour, Mohsen
    JOURNAL OF MOLECULAR MODELING, 2008, 14 (06) : 471 - 478
  • [5] SAR comparative studies on pyrimido[4,5-b][1,4] benzothiazine derivatives as 15-lipoxygenase inhibitors, using ab initio calculations
    Mehdi Bakavoli
    Hamid Sadeghian
    Zahra Tabatabaei
    Elham Rezaei
    Mohammad Rahimizadeh
    Mohsen Nikpour
    Journal of Molecular Modeling, 2008, 14
  • [6] A VERSATILE AND CONVENIENT METHOD FOR THE SYNTHESES OF PYRIMIDO[4,5-B][1,4]THIAZINE AND PYRIMIDO[4,5-B][1,4]THIAZEPINE RING-SYSTEMS
    SAKO, M
    TOTANI, R
    KONOHARA, M
    HIROTA, K
    MAKI, Y
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (11): : 2675 - 2677
  • [7] BROMINE SUBSTITUTION FOR HYDROGEN IN BROMOSUBSTITUTED TETRAHYDROPYRIMIDO[4,5-B][1,4]BENZOTHIAZINE UNDER IONIZING ELECTRON-IMPACT
    ANISIMOVA, OS
    PYKHOVA, MV
    NEMERYUK, MP
    SAPHONOVA, TS
    SHEINKER, YN
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1986, (11): : 1570 - 1571
  • [8] Investigation of redox transformations of dipyrimido[4,5-b][4′,5′-e][1,4]thiazine derivatives
    Nemeryuk, MP
    Grigoryev, NB
    Traven, NI
    Levina, VI
    Dekhtyarev, EV
    Safonova, TS
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1997, (10): : 1398 - 1401
  • [9] SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF SOME DERIVATIVES OF 3-PHENYLIMIDAZO[4,5-B]PYRIDINE
    KACZMAREK, L
    NANTKANAMIRSKI, P
    MORYL, E
    CHOJNACKAWOJCIK, E
    POLISH JOURNAL OF PHARMACOLOGY AND PHARMACY, 1990, 42 (01): : 79 - 84
  • [10] SYNTHESIS AND PROPERTIES OF PYRIDAZINO[4,5-B]QUINOLINE DERIVATIVES
    GODARD, A
    PASTOUR, P
    QUEGUINE.G
    BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, 1972, (04): : 1588 - &