THE POWER OF FOCUSED TESTS TO DETECT DISEASE CLUSTERING

被引:28
作者
WALLER, LA [1 ]
LAWSON, AB [1 ]
机构
[1] UNIV ABERTAY, DEPT MATH & COMP SCI, DUNDEE DD1 1HG, SCOTLAND
关键词
D O I
10.1002/sim.4780142103
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Statistical tests have been proposed for determining whether incident cases of adverse health effects are 'clustered' together, Several procedures, termed 'focused', specifically analyse disease surveillance data around pre-specified putative sources of environmental hazard. Little has been done to compare the performance of various proposed methods on actual models of clustering. Analytic power functions are derived for three tests of focused clustering. These functions are based on the probabilistic structure of the clustering tests and do not require simulation. The three tests are compared with respect to statistical power on hypothetical data where monotone multiplicative increases in disease risk near a putative hazard define disease clusters of varying intensity.
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页码:2291 / 2308
页数:18
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